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Invitrogen
CHMP2A Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-59454
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CHMP2A. Recombinant protein control fragment (Product #RP-99059).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NIQAVSLKIQ TLKSNNSMAQ AMKGVTKAMG TMNRQLKLPQ IQKIMMEFER QAEIMDMKEE MMNDAIDDAM
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A is required for both MVB formation and regulation of cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BC-2; BC-2; 32 kDa; chromatin modifying protein 2A; p32; putative breast adenocarcinoma marker; putative breast adenocarcinoma marker (32kD); putative breast adenocarcinoma marker BC-2; unnamed protein product; vacuolar protein sorting-associated protein 2-1; VPS2 homolog A; vps2-1
Gene Aliases: BC-2; BC2; CHMP2; VPS2; VPS2A
UniProt ID: (Human) O43633
Entrez Gene ID: (Human) 27243
plasma membrane repair
autophagy
nucleus organization
vacuolar transport
mitotic metaphase plate congression
membrane invagination
exit from mitosis
regulation of centrosome duplication
protein transport
macroautophagy
viral release from host cell
nuclear envelope reassembly
endosome transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
establishment of protein localization
late endosome to vacuole transport
viral budding from plasma membrane
protein polymerization
protein homooligomerization
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
positive regulation of exosomal secretion
negative regulation of centriole elongation
ESCRT III complex disassembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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