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Invitrogen
Phospho-FGFR4 (Tyr754) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-FGFR4 (Tyr754) Antibody (PA5-64582) in WB
Western Blot analysis of Phospho-FGFR4 (Tyr754) was performed using lysates of THP-1 cell (Left) and THP-1 cell Serum-free treated (Right). The membrane was probed with Phospho-FGFR4 (Tyr754) Polyclonal Antibody (Product # PA5-64582) using a dilution of 1:1,000.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-64582
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FGFR4 (Phospho-Tyr754)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Phospho-FGFR4 (Tyr754) Polyclonal Antibody detects endogenous levels of FGFR4 only when phosphorylated at Tyr754.
Target Information
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTLA-2-beta protein; FGF Receptor; FGF Receptor 4; FGFR; FGFR-4; FGFR4; FGFR4 isoform; exon 17 splice variant; FGFR4 variant; ptd-FGFR4; fibroblast growth factor receptor 4 16 minus form; hydroxyaryl-protein kinase; MGC20292; protein-tyrosine kinase; protein-tyrosine kinase receptor MPK-11; receptor tyrosine kinase; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase; unnamed protein product
Gene Aliases: CD334; Fgfr-4; JTK2; TKF
UniProt ID: (Human) P22455, (Mouse) Q03142, (Rat) Q498D6
Entrez Gene ID: (Human) 2264, (Mouse) 14186, (Rat) 25114
organ induction
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell communication
regulation of extracellular matrix disassembly
regulation of phosphate transport
cell migration
peptidyl-tyrosine phosphorylation
regulation of lipid metabolic process
positive regulation of signaling
lung development
glucose homeostasis
cholesterol homeostasis
positive regulation of catalytic activity
positive regulation of proteolysis
protein autophosphorylation
positive regulation of developmental process
regulation of phosphorus metabolic process
positive regulation of multicellular organismal process
phosphate ion homeostasis
alveolar secondary septum development
positive regulation of ERK1 and ERK2 cascade
vitamin D3 metabolic process
regulation of bile acid biosynthetic process
negative regulation of fibroblast growth factor production
positive regulation of DNA biosynthetic process
positive regulation of parathyroid hormone secretion
positive regulation of MAPK cascade
response to bile acid
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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