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Invitrogen
CTPS Polyclonal Antibody
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Product Details
PA5-65655
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human CTPS. Recombinant protein control fragment (Product #RP-104921).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PYFGLLLASVG RLSHYLQKGC RLSPRDTYSD RSGSSSPDSE ITELKFPSIN HD
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 94%.
Target Information
There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTP synthase 1; CTP synthetase 1; cytidine 5'-triphosphate synthetase; cytidine 5-prime triphosphate synthetase; Protein-asparagine deamidase CTPS1; unnamed protein product; UTP--ammonia ligase 1
Gene Aliases: CTPS; CTPS1; GATD5; GATD5A; IMD24
UniProt ID: (Human) P17812
Entrez Gene ID: (Human) 1503
immune system process
nucleobase-containing compound metabolic process
pyrimidine nucleotide biosynthetic process
CTP biosynthetic process
response to xenobiotic stimulus
pyrimidine nucleobase biosynthetic process
T cell proliferation
B cell proliferation
'de novo' CTP biosynthetic process
small molecule metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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