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Invitrogen
PITX2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-66524
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human PITX2. Recombinant protein control fragment (Product #RP-107189).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NLNNLSSPSLN SAVPTPACPY APPTPPY
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: all1-responsive gene 1; ALL1-responsive protein ARP1; homeobox protein PITX2; isoform a; isoform b; isoform c; paired-like homeodomain transcription factor 2; rieg bicoid-related homeobox transcription factor 1; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S α 1 glycoprotein; S α1glycoprotein; solurshin; unnamed protein product
Gene Aliases: ARP1; ASGD4; Brx1; IDG2; IGDS; IGDS2; IHG2; IRID2; Otlx2; PTX2; RGS; RIEG; RIEG1; RS
UniProt ID: (Human) Q99697
Entrez Gene ID: (Human) 5308
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
identical protein binding
protein homodimerization activity
ribonucleoprotein complex binding
sequence-specific DNA binding
phosphoprotein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
outflow tract morphogenesis
cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
determination of left/right symmetry
positive regulation of cell proliferation
anatomical structure morphogenesis
organ morphogenesis
hair cell differentiation
deltoid tuberosity development
odontogenesis
camera-type eye development
positive regulation of transcription from RNA polymerase II promoter
spleen development
system development
somatotropin secreting cell differentiation
prolactin secreting cell differentiation
embryonic heart tube left/right pattern formation
iris morphogenesis
left/right axis specification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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