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Invitrogen
FIG4 Polyclonal Antibody
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FIGURE: 1 / 1
FIG4 Antibody (PA5-68477) in WB
Western Blot analysis of FIG4 was performed using mouse-liver, HeLa 3, mouse-brain cells. The membrane was probed with FIG4 Polyclonal Antibody (Product # PA5-68477) using dilution 1:1,000 (4°C, overnight). Secondary antibody Goat Anti-rabbit IgG IRDye 800 diluted at 1:5,000 (25°C, 1 hour).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-68477
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human FIG4 [aa 341-390].
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FIG4 homolog; FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; KIAA0274; phosphatidylinositol 3,5-bisphosphate 5-phosphatase; RP1-249I4.1; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; serine-protein phosphatase FIG4; unnamed protein product
Gene Aliases: A530089I17Rik; ALS11; BOP; BTOP; CMT4J; dJ249I4.1; KIAA0274; SAC3; YVS
UniProt ID: (Human) Q92562, (Mouse) Q91WF7
Entrez Gene ID: (Human) 9896, (Mouse) 103199
phosphatidylinositol-3-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
protein serine/threonine phosphatase activity
protein binding
phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol bisphosphate phosphatase activity
phosphatidylinositol-4-phosphate phosphatase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
phosphatidylinositol biosynthetic process
positive regulation of neuron projection development
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol dephosphorylation
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
vacuole organization
locomotory behavior
negative regulation of myelination
myelin assembly
pigmentation
phosphatidylinositol metabolic process
neuron development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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