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Invitrogen
ABCA7 Polyclonal Antibody
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Product Details
PA5-69248
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide corresponding to a region of mouse ABCA7
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rat: 100%
Target Information
ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC 1 antibody; ABC Transporter 1; ABC1; ABC1 antibody; ABCA7; ATP-binding cassette, sub-family A (ABC1), member 7; CERP; CERP antibody; EC 2.2.1.1; EC 3.6.3; EC 3.6.3.41; FLJ40025
Gene Aliases: Abc51; ABCX
UniProt ID: (Mouse) Q91V24
Entrez Gene ID: (Mouse) 27403
protein binding
ATP binding
ATPase activity
apolipoprotein A-I receptor activity
ATPase activity, coupled to transmembrane movement of substances
phosphatidylcholine-translocating ATPase activity
phosphatidylserine-translocating ATPase activity
intermembrane phospholipid transfer activity
ATPase-coupled intramembrane lipid transporter activity
floppase activity
ABC-type transporter activity
memory
visual learning
positive regulation of cholesterol efflux
regulation of lipid metabolic process
cholesterol efflux
phospholipid efflux
beta-amyloid formation
high-density lipoprotein particle assembly
protein localization to nucleus
apolipoprotein A-I-mediated signaling pathway
negative regulation of amyloid precursor protein biosynthetic process
negative regulation of MAPK cascade
plasma membrane raft organization
phospholipid translocation
negative regulation of endocytosis
positive regulation of phagocytosis
transmembrane transport
membrane organization
positive regulation of ERK1 and ERK2 cascade
amyloid-beta clearance by cellular catabolic process
positive regulation of beta-amyloid clearance
positive regulation of engulfment of apoptotic cell
negative regulation of beta-amyloid formation
regulation of amyloid precursor protein catabolic process
positive regulation of phospholipid efflux
negative regulation of PERK-mediated unfolded protein response
regulation of protein localization to cell surface
positive regulation of protein localization to cell surface
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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