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Invitrogen
SAPK4 Polyclonal Antibody
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Product Details
PA5-70214
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human p38 MAPK delta
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 93%; Goat: 93%; Guinea Pig: 93%; Horse: 77%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Yeast: 85%; Zebrafish: 86%
Target Information
MAPK13 (p38 delta) is a serine/threonine kinase that transduces a variety of extracellular signals, including cytokine and environmental stress responses. MAPK13 also regulates the differentiation of keratinocytes. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases, or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of SAPK4 encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase 13; MAP kinase p38 delta; MAPK 13; MAPK13; mitogen-activated protein kinase p38 delta; new member of p38 MAP kinase subfamily; p38 delta MAP kinase; p38-delta MAPK; SAPK/Erk/kinase 4; SAPK4; stress-activated protein kinase 4; unnamed protein product
Gene Aliases: MAPK 13; MAPK-13; p38delta; PRKM13; SAPK4; Serk4
UniProt ID: (Human) O15264, (Mouse) Q9Z1B7
Entrez Gene ID: (Human) 5603, (Mouse) 26415
MAPK cascade
response to osmotic stress
positive regulation of interleukin-6 production
cellular response to stress
cellular response to UV
intracellular signal transduction
positive regulation of inflammatory response
stress-activated MAPK cascade
cellular response to hydrogen peroxide
cellular response to interleukin-1
cellular response to sorbitol
cellular response to anisomycin
cellular response to sodium arsenite
protein phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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