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REA Polyclonal Antibody
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FIGURE: 1 / 3
REA Antibody (PA5-70526) in WB
Western blot was performed using Anti-Prohibitin2 Polyclonal Antibody (Product # PA5-70526) and a 30 kDa band corresponding to Prohibitin2 , along with an uncharacterized band(*), was observed across cell lines and tissue tested. Whole cell extracts (30 µg lysate) of Caco-2 (Lane 1), Hep G2 (Lane 2), T-47D (Lane 3), A-431 (Lane 4), HeLa (Lane 5), NIH/3T3 (Lane 6) and PC-12 (Lane 7) and tissue extract of Mouse Heart (Lane 8) were electrophoresed using NuPAGE™ 12% Bis-Tris Protein Gel (Product # NP0341BOX). Resolved proteins were then transf... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-70526
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human REA (aa 191-240)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 86%; Zebrafish: 93%
Immunogen is a synthetic peptide located within the following region: REYTAAVEAK QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE
Target Information
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B cell receptor associated protein 37; B-cell associated protein; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; D-prohibitin; MGC117268; NB4 apoptosis/differentiation related protein; repressor of estrogen receptor activity; unnamed protein product
Gene Aliases: BAP; Bap37; BCAP37; hBAP; p22; PNAS-141; REA
UniProt ID: (Human) Q99623, (Mouse) O35129
Entrez Gene ID: (Human) 11331, (Mouse) 12034
mitophagy
positive regulation of immunoglobulin production
regulation of transcription from RNA polymerase II promoter
protein import into nucleus
mitochondrion organization
sister chromatid cohesion
cell migration
regulation of complement activation
RIG-I signaling pathway
B cell activation
negative regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of transcription, DNA-templated
protein stabilization
positive regulation of ERK1 and ERK2 cascade
antiviral innate immune response
regulation of cardiolipin metabolic process
positive regulation of NIK/NF-kappaB signaling
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of mammary gland epithelial cell proliferation
mammary gland branching involved in thelarche
mammary gland alveolus development
regulation of branching involved in mammary gland duct morphogenesis
regulation of cytochrome-c oxidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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