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Invitrogen
GLP1R Polyclonal Antibody
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Product Details
PA5-70645
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of mouse GLP1R
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 86%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 86%; Rabbit: 86%; Rat: 100%; Sheep: 86%
Target Information
Glucagon-like peptide-1(9-36)amide and GLP-1(9-37) are the forms of GLP-1 that result from the rapid degradation of the active forms of the peptide (GLP-1(7-36)amide and GLP-1(7-37)) by the enzyme dipeptidyl peptidase-IV (DPP-IV, also known as CD26 or adenosine deaminase binding protein). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 7 transmembrane domain protein; GLP-1 receptor; GLP-1-R; GLP-I receptor
Gene Aliases: GLP-1R; GLP1Rc
UniProt ID: (Mouse) O35659
Entrez Gene ID: (Mouse) 14652
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
learning or memory
memory
feeding behavior
regulation of heart contraction
positive regulation of cell proliferation
associative learning
response to glucose
protein transport
insulin secretion
posttranslational protein targeting to membrane, translocation
positive regulation of insulin secretion
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of cell differentiation
positive regulation of blood pressure
positive regulation of transcription from RNA polymerase II promoter
hormone secretion
release of sequestered calcium ion into cytosol
regulation of calcium ion transport
cellular response to glucagon stimulus
cAMP/PKA signal transduction
response to psychosocial stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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