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Invitrogen
Phospho-TSC1 (Ser1141) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-TSC1 (Ser1141) Antibody (PA5-72379) in DB
Dot blot analysis of Phospho-TSC1 (Ser1141). Samples were incubated with Phospho-TSC1 (Ser1141) polyclonal antibody (Product # PA5-72379) using a dilution of 0.6 µg/mL. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed on nitrocellulose membrane.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-72379
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1141 of rat TSC1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.28 mg/mL
Amount
112 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:12362; MGC86987; OTTHUMP00000022439; OTTHUMP00000198378; Tsc1; tuberous sclerosis 1 protein homolog
UniProt ID: (Rat) Q9Z136
Entrez Gene ID: (Rat) 60445
kidney development
neural tube closure
regulation of cell-matrix adhesion
adaptive immune response
protein folding
potassium ion transport
cell-matrix adhesion
nervous system development
negative regulation of cell proliferation
associative learning
adult locomotory behavior
cellular response to starvation
negative regulation of neuron projection development
positive regulation of macroautophagy
negative regulation of macroautophagy
hippocampus development
cerebral cortex development
response to nutrient levels
negative regulation of TOR signaling
negative regulation of ATPase activity
response to insulin
negative regulation of GTPase activity
cellular response to decreased oxygen levels
myelination
memory T cell differentiation
negative regulation of cell size
regulation of protein kinase activity
synapse organization
protein stabilization
regulation of stress fiber assembly
positive regulation of stress fiber assembly
regulation of cell cycle
regulation of focal adhesion assembly
positive regulation of focal adhesion assembly
cardiac muscle cell differentiation
activation of GTPase activity
glucose import across plasma membrane
negative regulation of cellular response to oxidative stress
response to peptide
negative regulation of TORC1 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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