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Invitrogen
RAB7A Polyclonal Antibody
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FIGURE: 1 / 7
RAB7A Antibody (PA5-72549) in IHC (P)
Immunohistochemistry analysis of RAB7A in paraformaldehyde-fixed, paraffin-embedded human skeletal muscle tissue sections. Samples were incubated with RAB7A polyclonal antibody (Product # PA5-72549) using a dilution of 1:25 for 1 hours at 37°C followed by an undiluted biotinylated goat polyvalent antibody. Tissue was fixed with formaldehyde and blocked with 3% BSA for 0.5 hour at room temperature; antigen r... View More
Product Details
PA5-72549
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 176-204 amino acids from the C-terminal region of human RAB7
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: rab-7; RAB7, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein BRL-RAS; Ras-related protein p23; Ras-related protein Rab-7a; unnamed protein product
Gene Aliases: CMT2B; PRO2706; RAB7; RAB7A
UniProt ID: (Human) P51149, (Mouse) P51150, (Rat) P09527
Entrez Gene ID: (Human) 7879, (Mouse) 19349, (Rat) 29448
autophagosome assembly
protein targeting to lysosome
lipid metabolic process
endocytosis
autophagy
epidermal growth factor catabolic process
endosome to lysosome transport
response to bacterium
protein transport
lipid catabolic process
viral release from host cell
protein to membrane docking
synaptic vesicle recycling via endosome
retrograde transport, endosome to Golgi
early endosome to late endosome transport
bone resorption
positive regulation of protein catabolic process
positive regulation of viral process
establishment of vesicle localization
protein localization to lysosome
lipophagy
phagosome maturation
phagosome acidification
phagosome-lysosome fusion
neurotransmitter receptor transport, postsynaptic endosome to lysosome
vesicle-mediated transport in synapse
endosome to plasma membrane protein transport
negative regulation of exosomal secretion
positive regulation of exosomal secretion
negative regulation of intralumenal vesicle formation
transport
intracellular protein transport
small GTPase mediated signal transduction
Rab protein signal transduction
regulation of autophagosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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