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Invitrogen
HMOX1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-72965
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to a C-terminal portion of the human Heme Oxygenase 1 protein (between residues 225-275).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.17 mg/mL
Amount
117 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 30% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heat shock protein, 32-kD; heme orygenase 1; heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1; hemoxygenase; HMOX1; P32 protein; unnamed protein product
Gene Aliases: bK286B10; D8Wsu38e; Hemox; Heox; HEOXG; Hmox; HMOX1D; HO-1; HO1; HSP32
UniProt ID: (Human) P09601, (Rat) P06762, (Mouse) P14901
Entrez Gene ID: (Human) 3162, (Rat) 24451, (Mouse) 15368
angiogenesis
endothelial cell proliferation
wound healing involved in inflammatory response
negative regulation of leukocyte migration
regulation of transcription from RNA polymerase II promoter
heme oxidation
cellular iron ion homeostasis
response to oxidative stress
smooth muscle hyperplasia
positive regulation of chemokine production
erythrocyte homeostasis
low-density lipoprotein particle clearance
cellular response to heat
response to nicotine
intracellular signal transduction
heme catabolic process
response to hydrogen peroxide
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of angiogenesis
positive regulation of angiogenesis
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
multicellular organismal iron ion homeostasis
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of ferroptosis
negative regulation of cytokine production involved in inflammatory response
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
response to hypoxia
phospholipid metabolic process
small GTPase mediated signal transduction
regulation of blood pressure
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
response to xenobiotic stimulus
negative regulation of muscle cell apoptotic process
positive regulation of macroautophagy
negative regulation of macroautophagy
cellular response to nutrient
negative regulation of mast cell cytokine production
heme metabolic process
positive regulation of apoptotic process
negative regulation of mast cell degranulation
negative regulation of neuron apoptotic process
response to estrogen
negative regulation by host of viral transcription
cellular response to arsenic-containing substance
cellular response to cadmium ion
cellular response to cisplatin
liver regeneration
negative regulation of viral life cycle
negative regulation of epithelial cell apoptotic process
response to arachidonate
response to 3-methylcholanthrene
negative regulation of vascular smooth muscle cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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