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Invitrogen
AANAT Polyclonal Antibody
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FIGURE: 1 / 6
AANAT Antibody (PA5-75722) in IHC (P)
Immunohistochemistry analysis of AANAT in paraffin-embedded human breast carcinoma tissue (cytoplasmic strong positive staining) and negative control (right, with PBS only). Samples were incubated with AANAT polyclonal antibody (Product # PA5-75722) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-75722
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human AANAT
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis. Hormonal melatonin has been implicated in sleep and circadian clock function. Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina. Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein. Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity. This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AA-NAT; Aralkylamine N-acetyltransferase; arylakylamine N-acetyltransferase; Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase); arylalkylamine N-acetyltransferase; Seretonin N-acetyltransferase; Serotonin acetylase; Serotonin N-acetyltransferase
Gene Aliases: AA-NAT; AANAT; DSPS; Nat4; SNAT
UniProt ID: (Human) Q16613, (Rat) Q64666
Entrez Gene ID: (Human) 15, (Rat) 25120
aralkylamine N-acetyltransferase activity
arylamine N-acetyltransferase activity
protein binding
N-acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring acyl groups other than amino-acyl groups
14-3-3 protein binding
acetyltransferase
N-terminal protein amino acid acetylation
circadian rhythm
response to light stimulus
photoperiodism
response to zinc ion
melatonin biosynthetic process
response to insulin
response to cytokine
response to prostaglandin E
indolalkylamine biosynthetic process
response to copper ion
rhythmic process
response to corticosterone
response to cAMP
response to calcium ion
cellular response to cAMP
response to peptide
response to organic cyclic compound
entrainment of circadian clock by photoperiod
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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