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Invitrogen
P2X4 Polyclonal Antibody
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Product Details
PA5-76989
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human P2X4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; ATP-gated cation channel protein; ionotropic ATP receptor subtype; ionotropic purinergic receptor; ligand gated ion channel; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X4; purinergic receptor P2x4 subunit variant e; purinoceptor P2X4; unnamed protein product
Gene Aliases: AI504491; AW555605; D5Ertd444e; P2RX4; P2X4; P2X4R
UniProt ID: (Human) Q99571
Entrez Gene ID: (Human) 5025, (Mouse) 18438
nucleotide binding
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
receptor binding
ion channel activity
copper ion binding
protein binding
ATP binding
zinc ion binding
identical protein binding
cadherin binding
ligand-gated calcium channel activity
drug binding
ligand-gated ion channel
tissue homeostasis
regulation of sodium ion transport
response to ischemia
ion transport
response to stress
signal transduction
regulation of blood pressure
positive regulation of calcium ion transport into cytosol
negative regulation of cardiac muscle hypertrophy
regulation of metal ion transport
sensory perception of pain
calcium-mediated signaling
positive regulation of cell migration
positive regulation of prostaglandin secretion
response to ATP
ion transmembrane transport
response to fluid shear stress
purinergic nucleotide receptor signaling pathway
endothelial cell activation
positive regulation of blood vessel endothelial cell migration
positive regulation of nitric oxide biosynthetic process
behavioral response to pain
response to axon injury
positive regulation of calcium-mediated signaling
regulation of chemotaxis
sensory perception of touch
positive regulation of protein kinase B signaling
membrane depolarization
positive regulation of calcium ion transport
regulation of cardiac muscle contraction
relaxation of cardiac muscle
excitatory postsynaptic potential
calcium ion transmembrane transport
cellular response to zinc ion
cellular response to ATP
apoptotic signaling pathway
cation transmembrane transport
regulation of ruffle assembly
positive regulation of intracellular signal transduction
positive regulation of microglial cell migration
positive regulation of endothelial cell chemotaxis
nitric oxide biosynthetic process
transport
calcium ion transport
neuronal action potential
vasodilation
protein homooligomerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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