Search

  • Fale Conosco
  • Pedido rápido

Invitrogen

LARGE Polyclonal Antibody

View all (11) LARGE antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation'] || 'Additional Information'}}: {{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:

{{$ctrl.translations[$ctrl.isSkuNotesCollapsed ? 'antibody.pdp.skuNotes.viewMore' : 'antibody.pdp.skuNotes.viewLess']}}

Product Details

PA5-78393

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human LARGE. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736081

Product Specific Information

Positive Control: mouse liver

Predicted Reactivity: Human (100%), Rhesus Monkey (100%), Bovine (99%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The LARGE gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; glycosyltransferase-like protein LARGE1; LARGE; like-acetylglucosaminyltransferase; like-glycosyltransferase; myodystrophy; unnamed protein product

View more View less

Gene Aliases: BPFD#36; enr; fg; froggy; Gyltl1a; LARGE; Mbp-1; Mbp1; MDC1D; MDDGA6; MDDGB6; myd

View more View less

UniProt ID: (Human) O95461, (Mouse) Q9Z1M7

View more View less

Entrez Gene ID: (Human) 9215, (Mouse) 16795, (Rat) 361368

View more View less

Function(s)
protein binding acetylglucosaminyltransferase activity glucuronosyltransferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups manganese ion binding UDP-xylosyltransferase activity xylosyltransferase activity
Process(es)
N-acetylglucosamine metabolic process protein O-linked glycosylation glycosphingolipid biosynthetic process glycoprotein biosynthetic process negative regulation of muscle cell apoptotic process positive regulation of Rac protein signal transduction protein O-linked mannosylation skeletal muscle tissue regeneration muscle cell cellular homeostasis positive regulation of protein kinase B signaling skeletal muscle organ development positive regulation of skeletal muscle acetylcholine-gated channel clustering blood vessel development behavioral fear response neuron migration protein phosphorylation protein deglycosylation protein targeting to membrane water transport intracellular protein transport striated muscle contraction plasma membrane organization cytoskeleton organization chemical synaptic transmission neuromuscular synaptic transmission brain development heart development muscle organ development neuromuscular junction development sensory perception of sound memory protein localization determination of adult lifespan glycoprotein metabolic process response to light stimulus response to mechanical stimulus gene expression retina layer formation myotube differentiation dentate gyrus development nerve development principal sensory nucleus of trigeminal nerve development macrophage differentiation post-embryonic hindlimb morphogenesis multicellular organism growth myelination regulation of kinase activity post-translational protein modification regulation of synaptic plasticity astrocyte differentiation cardiac muscle tissue development skeletal muscle fiber development synapse organization neuromuscular process controlling posture neuromuscular process synaptic growth at neuromuscular junction localization of cell striated muscle cell development cardiac muscle cell development transmembrane transport retina development in camera-type eye limb development long-term synaptic potentiation bone development retina vasculature development in camera-type eye connective tissue development protein-containing complex assembly basement membrane organization potassium ion transmembrane transport protein localization to membrane protein localization to plasma membrane walking behavior acetylcholine receptor signaling pathway skeletal muscle fiber differentiation reactive gliosis biological_process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support