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Invitrogen
LMX1B Polyclonal Antibody
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FIGURE: 1 / 4
LMX1B Antibody (PA5-78395) in IHC (F)
LMX1B Polyclonal Antibody detects LMX1B protein expression by immunohistochemical analysis. Sample: Frozen sectioned E13.5 Rat brain. Green: LMX1B protein stained by LMX1B Polyclonal Antibody (Product # PA5-78395) diluted at 1:250. Blue: Fluoroshield with DAPI .
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-78395
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human LMX1B. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: mouse skeletal muscle
Predicted Reactivity: Human (100%), Pig (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
LMX1B, LIM homeobox transcription factor 1B, belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1B regulates mid-hindbrain patterning LMX1B-null mice embryos have a severe reduction in the number of midbrain dopaminergic neurons compared to wild-type. While LMX1B appears to be important for both the development and the survival of dopamine neurons, the related LMX1A is crucial for the differentiation of these cells. However, LMX1A and LMX1B function cooperatively to regulated the proliferation, specification and differentiation of midbrain dopaminergic neuronal progenitors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: LIM/homeobox protein 1.2; LMX-1.2; transcription factor
Gene Aliases: FSGS10; LMX1.2; NPS1
UniProt ID: (Human) O60663
Entrez Gene ID: (Human) 4010, (Rat) 114501
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
dorsal/ventral pattern formation
neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
dopaminergic neuron differentiation
neuron migration
trabecular meshwork development
memory
locomotory behavior
biological_process
cell proliferation
regulation of gene expression
cerebellum development
cerebellum morphogenesis
central nervous system neuron differentiation
central nervous system neuron development
collagen fibril organization
midbrain development
limb morphogenesis
organ growth
olfactory behavior
camera-type eye development
synapse organization
autophagosome-lysosome fusion
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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