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Invitrogen
CADM1 Polyclonal Antibody
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FIGURE: 1 / 2
CADM1 Antibody (PA5-78904) in WB
Western blot was performed using Anti-CADM1 Polyclonal Antibody (Product # PA5-78904) and a 58 kDa band corresponding to Cell adhesion molecule 1 was observed across cell lines tested except K-562 and Jurkat which is expected to be low. Membrane enriched extracts (30 µg lysate) of Daudi (Lane 1), Hep G2 (Lane 2), K-562 (Lane 3) and Jurkat (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blo... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-78904
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human SynCAM (73-92aa VIQLLNPNRQTIYFRDFRPL).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: A549 whole cell, JURKAT whole cell, RAJI whole cell, HELA whole cell.
Target Information
Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell adhesion molecule of the immunoglobulin superfamily; IGSF4; immunoglobulin superfamily member 4; immunoglobulin superfamily member 4A; immunoglobulin superfamily membrane protein; immunoglobulin-like cell adhesion molecule; immunosuperfamily protein Bl2; NECL-2; nectin-like 2; nectin-like protein 2; spermatogenic immunoglobulin superfamily; synaptic cell adhesion molecule; SynCAM1; TSLC-1; TSLC1/Nectin-like 2/IGSF4; TSLC1; membrane glycoprotein; tumor suppressor; tumor suppressor in lung cancer 1; unnamed protein product
Gene Aliases: 2900073G06Rik; 3100001I08Rik; BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175; RA175A; RA175B; RA175C; RA175N; SgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1
UniProt ID: (Human) Q9BY67, (Mouse) Q8R5M8
Entrez Gene ID: (Human) 23705, (Mouse) 54725
positive regulation of cytokine production
T cell mediated cytotoxicity
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell recognition
susceptibility to natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
activated T cell proliferation
detection of stimulus
lymphocyte migration into lymphoid organs
maintenance of postsynaptic specialization structure
retrograde trans-synaptic signaling by trans-synaptic protein complex
presynapse assembly
synaptic membrane adhesion
liver development
negative regulation of protein phosphorylation
cell adhesion
synapse assembly
unidimensional cell growth
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
bone development
negative regulation of ERBB4 signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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