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Invitrogen
Caveolin 2 Polyclonal Antibody
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FIGURE: 1 / 6
Caveolin 2 Antibody (PA5-78927) in ICC/IF
Immunocytochemistry analysis of Caveolin-2 using anti-Caveolin-2 antibody (Product # PA5-78927) . Caveolin-2 was detected in a section of A549 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-Caveolin-2 antibody (Product # PA5-78927) overnight at 4°C. DyLight®488 Conjuga... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-78927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human Caveolin-2 recombinant protein (Position: M1-D162).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL once reconstituted
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HT1080 whole cell, human U20S whole cell, human Caco-2 whole cell, human Hela whole cell, human A549 whole cell, rat lung tissue, mouse lung tissue. IHC: human rectal cancer tissue, rat lung tissue. ICC/IF: A549 cell. Flow: A549 cell.
Target Information
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; CAV2; caveolae; caveolae protein, 20-kD; caveolar marker protein; member of the caveolin gene family; MGC12294; Phospho-CAV2; unnamed protein product
Gene Aliases: CAV
UniProt ID: (Human) P51636, (Rat) Q2IBC5, (Mouse) Q9WVC3
Entrez Gene ID: (Human) 858, (Rat) 363425, (Mouse) 12390
protein binding
protein kinase binding
protein binding, bridging
D1 dopamine receptor binding
heterotrimeric G-protein binding
protein homodimerization activity
protein heterodimerization activity
binding, bridging
scaffold protein binding
SNARE binding
mitogen-activated protein kinase kinase kinase binding
phosphoprotein binding
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
vesicle fusion
mitochondrion organization
endoplasmic reticulum organization
regulation of mitotic nuclear division
G-protein coupled receptor signaling pathway
chemical synaptic transmission
negative regulation of cell proliferation
insulin receptor signaling pathway
vesicle organization
receptor-mediated endocytosis of virus by host cell
viral release from host cell
cell differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of MAPK cascade
positive regulation by host of viral process
skeletal muscle fiber development
regulation of cytosolic calcium ion concentration
positive regulation of dopamine receptor signaling pathway
caveola assembly
basement membrane organization
positive regulation of protein localization to nucleus
endocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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