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Invitrogen
GRK5 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79331
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human GRK5 (393-429aa KREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAK).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whole cell, human Hela whole cell, human A549 whole cell, rat heart tissue, mouse heart tissue. IHC: rat cardiac muscle tissue, mouse lung tissue, human placenta tissue.
Target Information
GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-CP4; g protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; unnamed protein product
Gene Aliases: 1200003L19Rik; AlphaCP-4; FP2025; GPRK5
UniProt ID: (Human) P34947, (Rat) Q62833, (Mouse) Q8VEB1, (Mouse) P57724
Entrez Gene ID: (Human) 2869, (Rat) 59075, (Mouse) 14773, (Mouse) 59092
desensitization of G-protein coupled receptor protein signaling pathway
signal transduction
tachykinin receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
regulation of signal transduction
response to cocaine
negative regulation of apoptotic process
fat cell differentiation
oligodendrocyte differentiation
regulation of cell cycle
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
regulation of mRNA stability
negative regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of mRNA splicing, via spliceosome
regulation of mRNA metabolic process
protein autophosphorylation
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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