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Invitrogen
IL-23 p19 Polyclonal Antibody
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FIGURE: 1 / 1
IL-23 p19 Antibody (PA5-79489) in WB
Western blot analysis of IL-23 p19 in Lane 1: human placenta tissue lysate, Lane 2: human PANC-1 cell lysate, Lane 3: rat lymph tissue lysate, Lane 4: rat small intestine tissue lysate, Lane 5: rat testis tissue lysate, Lane 6: rat ovary tissue lysate, Lane 7: mouse testis tissue lysate using 50 µg (reducing conditions) per well. Electrophoresis was performed on 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours and protein was transferred to a nitrocellulose membrane at 150mA for 50-90 minutes. Sample was blocked... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79489
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived human IL23 recombinant protein (Position: R20-R178).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, human PANC-1 cell, rat lymph tissue, rat small intestine tissue, rat testis tissue, rat ovary tissue, mouse testis tissue.
Target Information
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: il 23; IL 23 A; Il-12b; Il-12p40; IL-23; IL-23 subunit alpha; IL-23-A; IL-23p19; IL12B; Il12p40; il23; ILN; Interleukin; interleukin 12B; interleukin 23 p19 subunit; Interleukin 23, alpha subunit p19; interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; p40; RP23-388G23.1
Gene Aliases: IL-23; IL-23A; IL23P19; P19; SGRF
UniProt ID: (Human) Q9NPF7, (Mouse) Q9EQ14, (Rat) Q91Z84
Entrez Gene ID: (Human) 51561, (Mouse) 83430, (Rat) 155140
positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
immune response
JAK-STAT cascade
regulation of gene expression
negative regulation of interleukin-10 production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-17 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell proliferation
interleukin-23-mediated signaling pathway
T cell proliferation
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of memory T cell differentiation
positive regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
positive regulation of alpha-beta T cell activation
defense response to Gram-negative bacterium
positive regulation of NK T cell activation
positive regulation of NK T cell proliferation
positive regulation of neutrophil chemotaxis
receptor signaling pathway via STAT
positive regulation of leukocyte differentiation
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
positive regulation of natural killer cell activation
positive regulation of tissue remodeling
positive regulation of inflammatory response
positive regulation of NIK/NF-kappaB signaling
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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