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Invitrogen
IL-7 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79509
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of mouse IL7 (26-42aa ECHIKDKEGKAYESVLM).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL once reconstituted
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
5mg BSA, 0.9mg NaCl, 0.2mg Na2PO4
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human PC-3 whole cell. IHC: Mouse Spleen Tissue.
Target Information
Interleukin 7 (IL-7) is a hematopoietic cytokine that is constitutively produced by stromal cells from the bone marrow and thymus. IL-7 signals through the IL-7R to promote the differentiation of hematopoietic stem cells to lymphoid precursor cells, which give rise to T cells, B cells, and natural killer cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD127 antigen; cytokine; H-IL-7; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; IL7R; IL-7 receptor alpha chain; ILN; Interleukin; interleukin 7 precursor; interleukin 7 receptor alpha chain; interleukin-7 receptor precursor; Interleukin7; M-IL-7; soluble interleukin-7 receptor; unnamed protein product
Gene Aliases: A630026I06Rik; CD127; CDW127; hlb368; IL-7; IL-7R-alpha; IL-7Ralpha; IL7RA; IL7Ralpha; ILRA; IMD104; IMD130; lnc-IL7R; sIL-7R
UniProt ID: (Human) P13232, (Human) P16871, (Mouse) P10168, (Mouse) P16872
Entrez Gene ID: (Human) 3574, (Human) 3575, (Mouse) 16196, (Mouse) 16197
leukocyte homeostasis
positive regulation of cytokine-mediated signaling pathway
immune response
humoral immune response
JAK-STAT cascade
cell-cell signaling
positive regulation of cell proliferation
organ morphogenesis
cytokine-mediated signaling pathway
positive regulation of B cell proliferation
positive regulation of chemokine production
interleukin-7-mediated signaling pathway
negative regulation of tyrosine phosphorylation of STAT protein
negative regulation of apoptotic process
bone resorption
positive regulation of T cell differentiation
negative regulation of Fas signaling pathway
T cell lineage commitment
regulation of gene expression
positive regulation of gene expression
cellular homeostasis
negative regulation of catalytic activity
positive regulation of B cell differentiation
positive regulation of organ growth
homeostasis of number of cells within a tissue
regulation of peptidyl-tyrosine phosphorylation
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
cell morphogenesis
negative regulation of T cell mediated cytotoxicity
regulation of cell size
hemopoiesis
T cell differentiation
positive regulation of T cell differentiation in thymus
B cell proliferation
positive regulation of JAK-STAT cascade
lymph node development
homeostasis of number of cells
defense response to Gram-positive bacterium
negative regulation of T cell apoptotic process
positive regulation of STAT cascade
regulation of DNA recombination
signal transduction
cell surface receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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