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Invitrogen
CD49e (Integrin alpha 5) Polyclonal Antibody
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FIGURE: 1 / 4
CD49e (Integrin alpha 5) Antibody (PA5-79529) in IHC (P)
Immunohistochemistry (Paraffin) analysis of CD49e (Integrin alpha 5) in paraffin-embedded section of human placenta tissue using CD49e (Integrin alpha 5) Polyclonal Antibody (Product # PA5-79529). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibod... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79529
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived human Integrin alpha 5 recombinant protein (Position: F42-A263).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human A549 whole cell lysates, human Hela whole cell lysates, human placenta tissue lysates, rat brain tissue lysates, rat PC-12 whole cell lysates, mouse brain tissue lysates. IHC: human placenta tissue, rat bladder tissue .
Target Information
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD49 antigen-like family member E; fibronectin receptor alpha polypeptide; fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; integrin alpha 5 (fibronectin receptor alpha); integrin alpha-F; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITGA5/SLC9B1 fusion; surface glycoprotein receptor; unnamed protein product; very late activation protein 5, alpha subunit
Gene Aliases: CD49e; FNRA; Itga5_retired; VLA-5; VLA5; VLA5A
UniProt ID: (Human) P08648, (Mouse) P11688
Entrez Gene ID: (Human) 3678, (Rat) 315346, (Mouse) 16402
angiogenesis
formation of primary germ layer
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
female pregnancy
tissue development
positive regulation of cell-substrate adhesion
response to muscle activity
CD40 signaling pathway
positive regulation of cell migration
positive regulation of vascular endothelial growth factor receptor signaling pathway
cell-substrate adhesion
cell adhesion mediated by integrin
heterotypic cell-cell adhesion
wound healing, spreading of epidermal cells
endodermal cell differentiation
regulation of angiogenesis
cell-cell adhesion
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of sprouting angiogenesis
negative regulation of anoikis
cell-substrate junction assembly
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
memory
cell-cell adhesion mediated by integrin
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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