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Invitrogen
MYBPC3 Polyclonal Antibody
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FIGURE: 1 / 5
MYBPC3 Antibody (PA5-79714) in IHC (P)
Immunohistochemistry analysis of MYBPC3 on paraffin-embedded human mammary cancer tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with MYBPC3 polyclonal antibody (Product# PA5-79714) with a dilution of 1 µg/mL (overnight at 4°C), and followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-79714
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived human MYBPC3 recombinant protein (Position: Q1070-H1123).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat heart tissue, mouse heart tissue. IHC: rat heart tissue, human lung cancer tissue, human mammary cancer tissue, human rectal cancer tissue.
Target Information
Myosin binding protein C, cardiac-type (MYBPC3) is a thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments. It modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Mutations affecting the gene can result in cardiomyopathy - familial hypertrophic 4, cardiomyopathy - dilated 1MM, or left ventricular non-compaction 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiac C-protein; cardiac MyBP-C; DKFZp779E1762; myosin binding protein C, cardiac; sarcomeric protein; unnamed protein product
Gene Aliases: CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C
UniProt ID: (Human) Q14896, (Rat) P56741
Entrez Gene ID: (Human) 4607, (Rat) 295929, (Mouse) 17868
heart morphogenesis
regulation of striated muscle contraction
regulation of muscle filament sliding
sarcomere organization
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
regulation of cardiac muscle cell contraction
regulation of heart rate
regulation of heart contraction
myosin filament assembly
muscle contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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