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Invitrogen
SLC19A1 Polyclonal Antibody
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FIGURE: 1 / 1
SLC19A1 Antibody (PA5-80009) in WB
Western blot analysis of SLC19A1 in, Lane 1: rat brain tissue lysates, Lane 2: rat ovary tissue lysates, Lane 3: mouse brain tissue lysates, Lane 4: mouse testicular tissue lysates, Lane 5: mouse ovary tissue lysates, Lane 6: mouse NIH/3T3 whole cell lysates, Lane 7: human placenta tissue lysates, Lane 8: human HEK293 whole cell lysates, Lane 9: monkey COS-7 whole cell lysates, Lane 10: human PC-3 whole cell lysates, Lane 11: human 22RV1 whole cell lysates, Lane 12: human K562 whole cell lysates. Electrophoresis was performed on a 5-20% SD... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-80009
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human SLC19A1 (202-231aa FLKRPKRSLFFNRDDRGRCETSASELERMN).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL once reconstituted
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat brain tissue, rat ovary tissue, mouse brain tissue, mouse testicular tissue, mouse ovary tissue, mouse NIH/3T3 whole cell, human placenta tissue, human HEK293 whole cell, monkey COS-7 whole cell, human PC-3 whole cell, human 22RV1 whole cell, human K562 whole cell.
Target Information
Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclic dinucleotide:anion antiporter SLC19A1; folate transporter 1; folate:anion antiporter SLC19A1; IFC-1; intestinal folate carrier 1; intestinal folate carrier protein; methotrexate carrier 1; methotrexate carrier 2; methotrexate carrier 5; methotrexate carrier 6; organic anion transporter; placental folate transporter; plasma membrane folate antiporter SLC19A1; reduced folate carrier 1; reduced folate carrier protein; reduced folate transporter 1; RFC-1; RFC1; solute carrier family 19 (folate transporter), member 1; solute carrier family 19 (sodium/hydrogen exchanger), member 1; solute carrier family 19 member 1; unnamed protein product
Gene Aliases: CHMD; FOLT; hRFC; hSLC19A1; IFC-1; IFC1; IMD114; MEGAF; MTX-1; MTX1; REFC; RFC; RFC-1; RFC1; RFT-1
UniProt ID: (Human) P41440, (Mouse) P41438, (Rat) Q62866
Entrez Gene ID: (Human) 6573, (Mouse) 20509, (Rat) 29723
protein binding
folic acid binding
folic acid transporter activity
reduced folate carrier activity
antiporter activity
methotrexate transporter activity
transmembrane transporter activity
xenobiotic transporter activity
cyclic-GMP-AMP binding
vitamin transmembrane transporter activity
cyclic-GMP-AMP transmembrane transporter activity
drug transmembrane transport
female pregnancy
response to xenobiotic stimulus
response to toxic substance
folic acid transport
vitamin transport
methotrexate transport
transmembrane transport
anion transmembrane transport
reduced folate transmembrane transport
cyclic-GMP-AMP transmembrane import across plasma membrane
positive regulation of cGAS/STING signaling pathway
folic acid import into cell
folic acid metabolic process
transport across blood-brain barrier
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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