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Invitrogen
Catenin alpha-1 Polyclonal Antibody
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FIGURE: 1 / 7
Catenin alpha-1 Antibody (PA5-85298) in ICC/IF
alpha 1 catenin antibody [N3c2], Internal detects alpha 1 Catenin protein at cytoplasm and cell junction by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: alpha 1 Catenin protein stained by alpha 1 catenin antibody [N3c2], Internal (Product # PA5-85298) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [G... View More
Product Details
PA5-85298
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cat,
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human alpha 1 Catenin. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.87 mg/mL
Amount
87 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (91%), Xenopus laevis (93%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%).
Positive Control: 293T, A431, H1299, HeLaS3, HepG2, NIH-3T3, JC, PC-12.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 102 kDa cadherin-associated protein; [a]E-catenin; alpha E catenin; Alpha E-catenin; alpha(E)-catenin; alpha-E-catenin; cadherin associated protein; Cadherin-associated protein; CAP102; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha 1; Catenin alpha-1; catenin, alpha 1; epididymis secretory sperm binding protein; Renal carcinoma antigen NY-REN-13; unnamed protein product
Gene Aliases: 2010010M04Rik; AA517462; AI988031; CAP102; Catna1; ctnna; CTNNA1; MDBS2; MDPT2
UniProt ID: (Human) P35221, (Mouse) P26231, (Zebrafish) Q9PVF8
Entrez Gene ID: (Dog) 474698, (Human) 1495, (Rat) 307505, (Mouse) 12385, (Zebrafish) 30741
ovarian follicle development
apoptotic process
cell adhesion
establishment or maintenance of cell polarity
smoothened signaling pathway
integrin-mediated signaling pathway
neuroblast proliferation
negative regulation of neuroblast proliferation
protein localization
male gonad development
gap junction assembly
cell migration
axon regeneration
regulation of cell proliferation
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
apical junction assembly
response to estrogen
positive regulation of smoothened signaling pathway
cell motility
cellular response to indole-3-methanol
epithelial cell-cell adhesion
extrinsic apoptotic signaling pathway in absence of ligand
cell-cell adhesion
negative regulation of protein localization to nucleus
negative regulation of cell motility
negative regulation of integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
actin filament organization
aging
response to organic cyclic compound
cellular protein localization
protein heterooligomerization
tissue homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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