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Invitrogen

Lyn Polyclonal Antibody

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Product Details

PA5-85319

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Immunoprecipitation (IP)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human LYN. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792461

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (83%), Chicken (86%), Sheep (96%), Bovine (95%).

Positive Control: HeLa, THP-1, CD44-knockout HeLa.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ26625; lck/Yes-related novel protein tyrosine kinase; lyn protein non-receptor kinase; lyn tyrosine kinase; Src-family protein tyrosine kinase; unnamed protein product; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

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Gene Aliases: JTK8; p53Lyn; p56Lyn; SAIDV

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UniProt ID: (Human) P07948, (Rat) Q07014

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Entrez Gene ID: (Human) 4067, (Rat) 81515

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Function(s)
protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding platelet-derived growth factor receptor binding integrin binding protein binding ATP binding kinase activity enzyme binding receptor activator activity ubiquitin protein ligase binding immunoglobulin receptor binding gamma-tubulin binding glycosphingolipid binding ion channel binding macromolecular complex binding ephrin receptor binding phosphoprotein binding scaffold protein binding phosphorylation-dependent protein binding SH3 domain binding phosphatidylinositol 3-kinase activator activity
Process(es)
DNA damage checkpoint cell morphogenesis B cell homeostasis regulation of cytokine production negative regulation of protein phosphorylation hematopoietic progenitor cell differentiation Fc receptor mediated stimulatory signaling pathway tolerance induction to self antigen histamine secretion by mast cell platelet degranulation negative regulation of myeloid leukocyte differentiation immune response-regulating cell surface receptor signaling pathway Fc receptor mediated inhibitory signaling pathway regulation of B cell apoptotic process protein phosphorylation autophagy defense response inflammatory response cellular response to DNA damage stimulus response to sterol depletion transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus response to toxic substance response to hormone response to carbohydrate positive regulation of neuron projection development oligodendrocyte development fatty acid transport vesicle-mediated transport peptidyl-tyrosine phosphorylation hemopoiesis erythrocyte differentiation eosinophil differentiation positive regulation of cell migration negative regulation of B cell proliferation neuron projection development lipopolysaccharide-mediated signaling pathway response to insulin regulation of mast cell activation regulation of cell adhesion mediated by integrin negative regulation of toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway negative regulation of toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 4 signaling pathway positive regulation of toll-like receptor 9 signaling pathway cellular response to heat intracellular signal transduction interleukin-5-mediated signaling pathway C-X-C chemokine receptor CXCR4 signaling pathway B cell proliferation positive regulation of phosphorylation response to amino acid regulation of mast cell degranulation negative regulation of MAP kinase activity positive regulation of MAPK cascade response to peptide hormone regulation of erythrocyte differentiation protein autophosphorylation ephrin receptor signaling pathway response to axon injury regulation of inflammatory response B cell receptor signaling pathway regulation of B cell receptor signaling pathway negative regulation of B cell receptor signaling pathway regulation of release of sequestered calcium ion into cytosol positive regulation of glial cell proliferation positive regulation of Fc receptor mediated stimulatory signaling pathway regulation of ERK1 and ERK2 cascade negative regulation of ERK1 and ERK2 cascade positive regulation of oligodendrocyte progenitor proliferation negative regulation of mast cell proliferation positive regulation of mast cell proliferation cellular response to retinoic acid regulation of monocyte chemotaxis regulation of platelet aggregation dendritic cell differentiation neuroinflammatory response negative regulation of intracellular signal transduction positive regulation of amyloid precursor protein catabolic process positive regulation of dendritic cell apoptotic process regulation of protein phosphorylation stimulatory C-type lectin receptor signaling pathway innate immune response-activating signal transduction negative regulation of inflammatory response to antigenic stimulus signal transduction T cell costimulation Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of immune response leukocyte migration JAK-STAT cascade involved in growth hormone signaling pathway cellular response to lipid
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