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Invitrogen
CASK Polyclonal Antibody
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FIGURE: 1 / 4
CASK Antibody (PA5-85785) in ICC/IF
CASK Polyclonal Antibody detects CASK protein by immunofluorescent analysis. Sample: DIV14 rat E18 primary cortical neurons were fixed in 4% paraformaldehyde at RT for 15 min. Green: CASK protein stained by CASK Polyclonal Antibody (Product # PA5-85785) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody [GT1338] diluted at 1:500. Blue: Fluoroshield with DAPI .
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-85785
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of mouse CASK. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.77 mg/mL
Amount
77 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (92%), Rhesus Monkey (93%), Bovine (93%).
Positive Control: mouse brain, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium/calmodulin-dependent serine protein kinase (MAGUK family); MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; peripheral plasma membrane protein CASK-like; RP23-278L4.1; unnamed protein product
Gene Aliases: DXPri1; DXRib1; LIN-2; mLin-2; Pals3
UniProt ID: (Mouse) O70589, (Rat) Q62915
Entrez Gene ID: (Mouse) 12361, (Rat) 29647
negative regulation of cell-matrix adhesion
regulation of transcription from RNA polymerase II promoter
protein localization
negative regulation of keratinocyte proliferation
protein transport
positive regulation of insulin secretion
positive regulation of transcription from RNA polymerase II promoter
regulation of neurotransmitter secretion
positive regulation of transport
positive regulation of dendritic spine morphogenesis
negative regulation of wound healing
calcium ion import
protein localization to plasma membrane
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
regulation of synaptic vesicle exocytosis
cerebral cortex development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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