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Invitrogen
SUV39H1 Polyclonal Antibody
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FIGURE: 1 / 3
SUV39H1 Antibody (PA5-87177) in ICC/IF
Immunofluorescence analysis of Histone-lysine N-methyltransferase SUV39H1 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with SUV39H1 Polyclonal Antibody (Product # PA5-87177) at 1:100 in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa ... View More
Product Details
PA5-87177
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human SUV39H1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: H3-K9-HMTase 1; Histone H3-K9 methyltransferase 1; Histone-lysine N-methyltransferase SUV39H1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; located at OATL1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; pSUV39H; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1; Suv39h histone methyltransferase; SUV39H1; unnamed protein product
Gene Aliases: AI852103; AL022883; DXHXS7466e; H3-K9-HMTase 1; KMT1A; MG44; mIS6; RGD1565028; SUV39H; SUV39H1
UniProt ID: (Human) O43463, (Mouse) O54864
Entrez Gene ID: (Human) 6839, (Mouse) 20937, (Rat) 302553
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
chromatin binding
protein binding
methyltransferase activity
zinc ion binding
S-adenosylmethionine-dependent methyltransferase activity
transferase activity
histone methyltransferase activity
metal ion binding
histone methyltransferase activity (H3-K9 specific)
histone H3 methyltransferase activity
histone H3K9me2 methyltransferase activity
histone H3K9 trimethyltransferase activity
protein methyltransferase activity
histone-lysine N-methyltransferase activity
protein N-terminus binding
molecular_function
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
chromatin silencing at rDNA
blastocyst hatching
regulation of DNA repair
chromatin organization
rRNA processing
cellular response to DNA damage stimulus
circadian rhythm
determination of adult lifespan
cell differentiation
regulation of bone mineralization
heterochromatin assembly
methylation
regulation of multicellular organism growth
cellular response to glucose starvation
epigenetic programming in the zygotic pronuclei
negative regulation of cell cycle
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
regulation of transcription by glucose
rhythmic process
cellular response to hypoxia
energy homeostasis
regulation of cellular senescence
DNA packaging
chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
protein methylation
cell cycle
chromatin modification
histone lysine methylation
histone H3-K9 dimethylation
histone H3-K9 trimethylation
negative regulation of circadian rhythm
histone H3-K9 methylation
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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