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Invitrogen

GluR2 Polyclonal Antibody

View all (49) GluR2 antibodies

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GluR2 Polyclonal Antibody

Product Details

PA5-87355

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 25-230 of human GluR2/GluR2/GRIA2 (NP_0010770881)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.52 mg/mL

Amount

52 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804088

Product Specific Information

Immunogen sequence: NSIQIGGLFP RGADQEYSAF RVGMVQFSTS EFRLTPHIDN LEVANSFAVT NAFCSQFSRG VYAIFGFYDK KSVNTITSFC GTLHVSFITP SFPTDGTHPF VIQMRPDLKG ALLSLIEYYQ WDKFAYLYDS DRGLSTLQAV LDSAAEKKWQ VTAINVGNIN NDKKDEMYRS LFQDLELKKE RRVILDCERD KVNDIVDQVI TIGKHV; Positive Samples: SH-SY5Y, HL-60, Mouse liver, Mouse brain, Mouse pancreas, Rat brain; Cellular Location: Cell junction, Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse

Target Information

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5 -methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AMPA receptor subunit GluA2; AMPA selective glutamate receptor; AMPA-selective glutamate receptor 2; GluR2; glutamate receptor; glutamate receptor B; glutamate receptor ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA 2; OTTHUMP00000165324; OTTHUMP00000220942; OTTHUMP00000220943; unnamed protein product

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Gene Aliases: GluA2; Glur-2; GluR-B; GluR-K2; GLUR2; GLURB; HBGR2; NEDLIB

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UniProt ID: (Human) P42262

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Entrez Gene ID: (Human) 2891, (Mouse) 14800

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Function(s)
beta-amyloid binding ionotropic glutamate receptor activity AMPA glutamate receptor activity ion channel activity protein binding ligand-gated ion channel activity signaling receptor activity ligand-gated monoatomic cation channel activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential SNARE binding extracellular ligand-gated ion channel activity extracellular-glutamate-gated ion channel activity cytoskeletal protein binding kainate selective glutamate receptor activity immunoglobulin binding protein kinase binding glutamate-gated calcium ion channel activity PDZ domain binding glutamate receptor binding ionotropic glutamate receptor binding identical protein binding macromolecular complex binding scaffold protein binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
Process(es)
regulation of receptor recycling ion transport chemical synaptic transmission calcium-mediated signaling receptor internalization ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic establishment of protein localization modulation of synaptic transmission positive regulation of synaptic transmission protein tetramerization regulation of synaptic plasticity by chemical substance regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential AMPA glutamate receptor clustering cation transmembrane transport regulation of presynaptic membrane potential regulation of long term synaptic depression response to phorbol 13-acetate 12-myristate cellular response to glycine cellular response to brain-derived neurotrophic factor stimulus conditioned place preference positive regulation of excitatory postsynaptic potential
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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