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Invitrogen
IGFBP2 Polyclonal Antibody
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FIGURE: 1 / 1
IGFBP2 Antibody (PA5-87431) in WB
Western blot analysis of IGFBP2 in extracts of various cell lines. Samples were incubated with IGFBP2 Polyclonal antibody (Product # PA5-87431) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-87431
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human IGFBP2 (NP_0005882)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.51 mg/mL
Amount
51 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ACGVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT E; Positive Samples: LO2, HeLa, SW480
Target Information
IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IGF binding protein 2; IGF-binding protein 2; IGFBP; Insulin like growth factor binding protein; insulin-like growth factor binding protein 2; insulin-like growth factor binding protein 2, 36kDa; OTTHUMP00000207753; unnamed protein product
Gene Aliases: IBP2; IGF-BP53
UniProt ID: (Human) P18065
Entrez Gene ID: (Human) 3485
osteoblast differentiation
female pregnancy
response to nutrient
response to xenobiotic stimulus
response to mechanical stimulus
response to estradiol
response to retinoic acid
cellular response to hormone stimulus
positive regulation of activated T cell proliferation
regulation of insulin-like growth factor receptor signaling pathway
response to estrogen
response to steroid hormone
response to glucocorticoid
negative regulation of canonical Wnt signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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