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Invitrogen

beta Arrestin 1 Polyclonal Antibody

View all (28) beta Arrestin 1 antibodies

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beta Arrestin 1 Polyclonal Antibody

Product Details

PA5-87555

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 169-418 of human beta-arrestin1 (NP_0040322)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.85 mg/mL

Amount

185 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804249

Product Specific Information

Immunogen sequence: RKVQYAPERP GPQPTAETTR QFLMSDKPLH LEASLDKEIY YHGEPISVNV HVTNNTNKTV KKIKISVRQY ADICLFNTAQ YKCPVAMEEA DDTVAPSSTF CKVYTLTPFL ANNREKRGLA LDGKLKHEDT NLASSTLLRE GANREILGII VSYKVKVKLV VSRGGLLGDL ASSDVAVELP FTLMHPKPKE EPPHREVPEN ETPVDTNLIE LDTNDDDIVF EDFARQRLKG MKDDKEEEED GTGSPQLNNR; Positive Samples: U-937, K-562, Mouse brain, Mouse spleen; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus, clathrin-coated pit, pseudopodium

Target Information

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: arrestin; arrestin 2; Arrestin beta-1; beta-arrestin; Beta-arrestin-1; beta-arrestin1; Non-visual arrestin-2; unnamed protein product

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Gene Aliases: 1200006I17Rik; ARB1; ARR1; ARRB1; AW208571; BARRES; G430100A01Rik

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UniProt ID: (Human) P49407, (Rat) P29066, (Mouse) Q8BWG8

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Entrez Gene ID: (Human) 408, (Rat) 25387, (Mouse) 109689

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Function(s)
G-protein coupled receptor binding transcription coactivator activity histone acetyltransferase activity enzyme inhibitor activity GTPase activator activity insulin-like growth factor receptor binding protein binding enzyme binding ubiquitin protein ligase binding angiotensin receptor binding binding, bridging arrestin family protein binding transcription factor binding clathrin binding estrogen receptor binding mitogen-activated protein kinase kinase binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding follicle-stimulating hormone receptor binding V2 vasopressin receptor binding AP-2 adaptor complex binding clathrin adaptor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process transcription regulatory region DNA binding ion channel binding protein phosphorylated amino acid binding phosphoprotein binding scaffold/adaptor protein
Process(es)
positive regulation of protein phosphorylation desensitization of G-protein coupled receptor protein signaling pathway G-protein coupled receptor internalization positive regulation of receptor internalization regulation of transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process signal transduction sensory perception negative regulation of signal transduction positive regulation of cardiac muscle hypertrophy protein transport protein ubiquitination negative regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity negative regulation of interleukin-6 production negative regulation of interleukin-8 production positive regulation of Rho protein signal transduction stress fiber assembly proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of ERK1 and ERK2 cascade positive regulation of intracellular signal transduction activation of MAPK activity negative regulation of protein phosphorylation desensitization of G-protein coupled receptor protein signaling pathway by arrestin transcription from RNA polymerase II promoter endocytosis receptor-mediated endocytosis G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway phototransduction regulation of G-protein coupled receptor protein signaling pathway sensory perception of pain regulation of cAMP biosynthetic process regulation of cAMP catabolic process positive regulation of protein ubiquitination positive regulation of protein binding positive regulation of peptidyl-serine phosphorylation negative regulation of GTPase activity positive regulation of smooth muscle cell apoptotic process positive regulation of histone acetylation positive regulation of insulin secretion involved in cellular response to glucose stimulus follicle-stimulating hormone signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of GTPase activity sensory perception of touch negative regulation of ERK1 and ERK2 cascade positive regulation of histone H4 acetylation transcription, DNA-templated regulation of transcription, DNA-templated transport
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