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Invitrogen
SNAPAP Polyclonal Antibody
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FIGURE: 1 / 3
SNAPAP Antibody (PA5-87783) in IHC (P)
Immunohistochemistry analysis of SNAPAP in paraffin-embedded rat kidney. Samples were incubated with SNAPAP Polyclonal antibody (Product # PA5-87783) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-87783
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human SNAPIN (NP_0365691)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
4.2 mg/mL
Amount
420 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAGAGSAAVS GAGTPVAGPT GRDLFAEGLL EFLRPAVQQL DSHVHAVRES QVELREQIDN LATELCRINE DQKVALDLDP YVKKLLNARR RVVLVNNILQ NAQERLRRLN HSVAKETARR RAMLDSGIYP PGSPGK; Positive Samples: U-87MG, A-375, HeLa, Jurkat, Mouse lung, Mouse heart, Rat kidney; Cellular Location: Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Golgi apparatus membrane, Membrane, Peripheral membrane protein, perinuclear region, secretory vesicle, synaptic vesicle membrane
Target Information
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: biogenesis of lysosomal organelles complex-1, subunit 7; biogenesis of lysosome-related organelles complex 1 subunit 7; BLOC-1 related complex subunit 3; BLOC-1 subunit 7; SNAP-25-binding protein; SNARE associated protein snapin; SNARE-associated protein; synaptosomal-associated protein 25 binding protein; synaptosomal-associated protein 25-binding protein; synaptosomal-associated protein, 25 kDa, binding protein; unnamed protein product
Gene Aliases: 25kDa; BLOC1S7; BLOS7; BORCS3; NEDBAC; Snap25bp; SNAPAP
UniProt ID: (Human) O95295, (Rat) P60192, (Mouse) Q9Z266
Entrez Gene ID: (Human) 23557, (Rat) 295217, (Mouse) 20615
intracellular protein transport
lysosome organization
lysosomal lumen acidification
chemical synaptic transmission
anterograde axonal transport
retrograde axonal transport
endosome to lysosome transport
negative regulation of neuron projection development
synaptic vesicle exocytosis
synaptic vesicle maturation
insulin secretion
neuron projection development
protein complex localization
synaptic vesicle fusion to presynaptic active zone membrane
lysosome localization
synaptic vesicle transport
anterograde synaptic vesicle transport
protein maturation
terminal button organization
autophagosome maturation
late endosome to lysosome transport
regulation of synaptic vesicle exocytosis
neurotransmitter secretion
melanosome organization
regulation of endosome size
regulation of lysosome size
organelle transport along microtubule
positive regulation of late endosome to lysosome transport
calcium ion regulated exocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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