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Invitrogen

STAR Polyclonal Antibody

View all (34) STAR antibodies

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STAR Polyclonal Antibody

Product Details

PA5-87831

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 64-285 of human StAR (NP_0003402)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.28 mg/mL

Amount

128 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804439

Product Specific Information

Immunogen sequence: EETLYSDQEL AYLQQGEEAM QKALGILSNQ EGWKKESQQD NGDKVMSKVV PDVGKVFRLE VVVDQPMERL YEELVERMEA MGEWNPNVKE IKVLQKIGKD TFITHELAAE AAGNLVGPRD FVSVRCAKRR GSTCVLAGMA TDFGNMPEQK GVIRAEHGPT CMVLHPLAGS PSKTKLTWLL SIDLKGWLPK SIINQVLSQT QVDFANHLRK RLESHPASEA RC; Positive Samples: Jurkat; Cellular Location: Mitochondrion

Target Information

Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cholesterol trafficker; luteinizing hormone-induced protein; mitochondrial steroid acute regulatory protein; STAR; StAR related lipid transfer (START) domain containing 1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; testis secretory sperm-binding protein Li 241mP; unnamed protein product

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Gene Aliases: D8Ertd419e; STARD1

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UniProt ID: (Human) P49675, (Mouse) P51557

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Entrez Gene ID: (Human) 6770, (Mouse) 20845

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Function(s)
protein binding lipid binding cholesterol binding intermembrane cholesterol transfer activity molecular carrier activity
Process(es)
steroid biosynthetic process C21-steroid hormone biosynthetic process glucocorticoid biosynthetic process steroid metabolic process cholesterol metabolic process intracellular cholesterol transport regulation of steroid biosynthetic process positive regulation of bile acid biosynthetic process lipid metabolic process bile acid biosynthetic process estrogen biosynthetic process response to nutrient circadian rhythm glucocorticoid metabolic process male gonad development response to xenobiotic stimulus response to herbicide response to toxic substance response to ionizing radiation response to lead ion positive regulation of gene expression response to activity response to insecticide response to nutrient levels response to retinoic acid cellular response to insulin stimulus response to gonadotropin response to nicotine cellular response to interferon-alpha response to hydrogen peroxide response to peptide hormone negative regulation of neuron apoptotic process response to estrogen response to leptin cellular response to fibroblast growth factor stimulus response to ethanol regulation of neuronal synaptic plasticity response to steroid hormone positive regulation of neurogenesis response to corticosterone response to fungicide cellular response to lipopolysaccharide cellular response to antibiotic cellular response to metal ion cellular response to cadmium ion cellular response to alkaloid cellular response to cAMP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to growth hormone stimulus cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus cellular response to epinephrine stimulus response to benzoic acid
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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