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Invitrogen
DNMT3B Polyclonal Antibody
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Product Details
PA5-88070
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human DNMT3B (NP_0088231)
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Amount
95 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES
Positive Samples: LO2, 22Rv1, U-251MG, Mouse testis, Mouse kidney; Cellular Location: Nucleus
Target Information
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: de novo DNA methyltransferase; DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA cytosine-5--methyltransferase 3 beta; DNA methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA methyltransferase MmuIIIB; DNA MTase HsaIIIB; DNA MTase MmuIIIB; Dnmt3; Dnmt3b; DNMT3B1; DNMT3B4; DNMT3B5; DNMT3B7; m.MmuIIIB; MGC1090; unnamed protein product
Gene Aliases: DNMT3B; FSHD4; ICF; ICF1; M.HsaIIIB; MmuIIIB
UniProt ID: (Human) Q9UBC3, (Mouse) O88509
Entrez Gene ID: (Human) 1789, (Mouse) 13436, (Rat) 444985
DNA binding
transcription corepressor activity
DNA (cytosine-5-)-methyltransferase activity
protein binding
methyltransferase activity
zinc ion binding
DNA-methyltransferase activity
transferase activity
metal ion binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
chromatin binding
histone deacetylase binding
unmethylated CpG binding
DNA methyltransferase
negative regulation of transcription from RNA polymerase II promoter
regulation of gene expression
positive regulation of gene expression
methylation
DNA methylation
methylation-dependent chromatin silencing
regulation of gene expression by genetic imprinting
DNA methylation on cytosine within a CG sequence
protein complex localization
positive regulation of neuron differentiation
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
inactivation of X chromosome by DNA methylation
cellular response to amino acid stimulus
C-5 methylation of cytosine
response to hypoxia
response to toxic substance
response to ionizing radiation
response to activity
response to caffeine
response to estradiol
response to vitamin A
response to cocaine
response to drug
cellular response to hyperoxia
cellular response to dexamethasone stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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