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Invitrogen
ITPA Polyclonal Antibody
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FIGURE: 1 / 1
ITPA Antibody (PA5-88421) in WB
Western blot analysis of ITPA in extracts of various cell lines. Samples were incubated with ITPA Polyclonal antibody (Product # PA5-88421) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Product Details
PA5-88421
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-194 of human ITPA (NP_2584121)
Conjugate
Form
Liquid
Concentration
0.58 mg/mL
Amount
58 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAASLVGKKI VFVTGNAKKL EEVVQILGDK FPCTLVAQKI DLPEYQGEPD EISIQKCQEA VRQVQGPVLV EDTCLCFNAL GGLPGPYIKW FLEKLKPEGL HQLLAGFEDK SAYALCTFAL STGDPSQPVR LFRGRTSGRI VAPRGCQDFG WDPCFQPDGY EQTYAEMPKA EKNAVSHRFR ALLELQEYFG SLAA; Positive Samples: U-87MG, HT-29, Mouse small intestine, Mouse heart, Rat liver; Cellular Location: Cytoplasm
Target Information
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; inosine triphosphatase (nucleoside triphosphate pyrophosphatase); inosine triphosphatase (nucleoside triphosphate pyrophosphatase) isoform ITPA_1; inosine triphosphatase (nucleoside triphosphate pyrophosphatase) isoform ITPA_2; inosine triphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Inosine triphosphate pyrophosphatase; inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; inosine triphosphate pyrophosphohydrolase; ITPase; ITPase {ECO:0000255|HAMAP-Rule:MF_03148}; My049 protein; Non-canonical purine NTP pyrophosphatase; non-canonical purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Non-standard purine NTP pyrophosphatase; non-standard purine NTP pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; NTPase; NTPase {ECO:0000255|HAMAP-Rule:MF_03148}; nucleoside triphosphate pyrophosphatase; Nucleoside-triphosphate diphosphatase; nucleoside-triphosphate diphosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Nucleoside-triphosphate pyrophosphatase; nucleoside-triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}; Putative oncogene protein hlc14-06-p; XTP/dITP diphosphatase
Gene Aliases: 2010016I08Rik; AU020102; C20orf37; DEE35; dJ794I6.3; HLC14-06-P; Itp; ITPA; ITPase; My049; NTPase; OK/SW-cl.9
UniProt ID: (Human) Q9BY32, (Rat) D3ZW55, (Mouse) Q9D892
Entrez Gene ID: (Human) 3704, (Rat) 311422, (Mouse) 16434
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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