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Invitrogen
GUCY1A3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-88718
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GUCY1A3 (NP_0008472)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.19 mg/mL
Amount
219 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE; Positive Samples: U-87MG, A-549, 293T, Mouse kidney, Mouse brain, Rat kidney, Rat spleen, Rat lung; Cellular Location: Cytoplasm
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4.6.1.2; alpha3-like; GCS-alpha-1; GCS-alpha-3; GCS-alpha1; GCSalpha1; guanylate cyclase 1 soluble subunit alpha 3; guanylate cyclase 1, soluble, alpha 3; guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); GUCY1A1; soluble guanylate cyclase large subunit; unnamed protein product
Gene Aliases: 1200016O07Rik; GC-S-alpha-1; GC-SA3; GCS-alpha-1; GCS-alpha-3; GUC1A3; GUCA3; GUCSA3; GUCY1A3; MYMY6; SGC; sGC-alpha1
UniProt ID: (Human) Q02108, (Mouse) Q9ERL9
Entrez Gene ID: (Human) 2982, (Rat) 497757, (Mouse) 60596
cGMP biosynthetic process
regulation of blood pressure
cyclic nucleotide biosynthetic process
response to herbicide
intracellular signal transduction
nitric oxide-cGMP-mediated signaling pathway
relaxation of vascular smooth muscle
response to oxygen levels
retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission
positive regulation of nitric oxide-cGMP mediated signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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