Search
Invitrogen
SMYD3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-89877
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human SMYD3 (NP_0011612121)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.34 mg/mL
Amount
34 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DRCLLGKEKL MRCSQCRVAK YCSAKCQKKA WPDHKRECKC LKSCKPRYPP DSVRLLGRVV FKLMDGAPSE SEKLYSFYDL ESNINKLTED KKEGLRQLVM T; Positive Samples: 22Rv1, HT-29, HepG2, MCF7, HeLa, Mouse testis; Cellular Location: Cytoplasm, Nucleus
Target Information
SMYD3 (histone-lysine N-methyltransferase) methylates Lys-4 of histone H3 and Lys-5 of histone H4. It induces di- and tri-methylation. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: SET and MYND domain-containing protein 3; SET domain; unnamed protein product; zinc finger MYND domain-containing protein 1; zinc finger protein, subfamily 3A (MYND domain containing), 1; zinc finger, MYND domain containing 1
Gene Aliases: 2410008A19Rik; bA74P14.1; KMT3E; ZMYND1; ZNFN3A1
UniProt ID: (Human) Q9H7B4, (Mouse) Q9CWR2
Entrez Gene ID: (Human) 64754, (Rat) 498295, (Mouse) 69726
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core binding
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
protein binding
histone methyltransferase activity
histone H4 methyltransferase activity
histone H3K36 dimethyltransferase activity
histone H3K4 trimethyltransferase activity
chromatin remodeling
heart development
negative regulation of transcription, DNA-templated
nucleosome assembly
negative regulation of protein kinase activity
biological_process
myotube cell development
positive regulation of peptidyl-serine phosphorylation
establishment of protein localization
positive regulation of transcription from RNA polymerase II promoter
cellular response to dexamethasone stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support