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Invitrogen
FNTB Polyclonal Antibody
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FIGURE: 1 / 1
FNTB Antibody (PA5-90610) in WB
Western blot analysis of FNTB in extracts of various cell lines. Samples were incubated with FNTB Polyclonal antibody (Product # PA5-90610) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
Product Details
PA5-90610
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human FNTB (NP_0020191)
Conjugate
Form
Liquid
Concentration
0.87 mg/mL
Amount
87 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MASPSSFTYY CPPSSSPVWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK VEEKIQEVFS SYKFNHLVPR LVLQREKHFH YLKRGLRQLT DAYECLDASR PWLCYWILHS LELLDEPIPQ; Positive Samples: 293T, HeLa, HepG2, K-562, Mouse brain, Rat brain
Target Information
Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAAX farnesyltransferase subunit beta; EC 2.5.1.58; epididymis secretory sperm binding protein; farnesyltransferase beta subunit; farnesyltransferase, CAAX box, beta; ft beta; FTase beta; FTase-beta; Protein farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta; unnamed protein product
Gene Aliases: 2010013E13Rik; AA409500; FNTB; FPTB
UniProt ID: (Human) P49356, (Rat) Q02293, (Mouse) Q8K2I1
Entrez Gene ID: (Human) 2342, (Rat) 64511, (Mouse) 110606
catalytic activity
prenyltransferase activity
protein farnesyltransferase activity
protein binding
zinc ion binding
protein prenyltransferase activity
acetyltransferase activator activity
transferase activity
enzyme binding
peptide binding
metal ion binding
farnesyltranstransferase activity
drug binding
isoprenoid binding
acyltransferase
lipid metabolic process
positive regulation of cell proliferation
protein farnesylation
positive regulation of cell cycle
regulation of microtubule-based movement
negative regulation of cell proliferation
response to inorganic substance
response to organic cyclic compound
response to cytokine
wound healing
positive regulation of fibroblast proliferation
positive regulation of nitric-oxide synthase biosynthetic process
regulation of cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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