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Invitrogen
LILRB3 Polyclonal Antibody
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FIGURE: 1 / 1
LILRB3 Antibody (PA5-90933) in WB
Western blot analysis of LILRB3 in extracts of Jurkat cells. Samples were incubated with LILRB3 Polyclonal antibody (Product # PA5-90933) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-90933
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human LILRB3 (NP_0013078891)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.07 mg/mL
Amount
107 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RSSNPHLLSF PSEPLELMVS GHSGGSSLPP TGPPSTPGGP EDQPLNPPGS GPQNGLGRYL EVLIGVSVAF VLLLFLLLFL LLLRQRHSKH RTSDQRKTDF Q; Positive Samples: Jurkat; Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD85 antigen-like family member A; Cell-surface glycoprotein p91; ILT5 016; ILT5 018; ILT5 023; ILT5 024; ILT5 026; ILT5 029; immunoglobulin superfamily; immunoglobulin-like transcript 5; inhibitory receptor; leucocyte Ig-like receptor B3; leukocyte immunoglobulin-like receptor 3; Leukocyte immunoglobulin-like receptor subfamily B member 3; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; LIR-3; monocyte inhibitory receptor HL9; Paired immunoglobulin-like receptor B; PIR-B; surface molecule; surface molecule; less common antigenic variant; unnamed protein product
Gene Aliases: CD85A; Gp91; HL9; ILT-5; ILT5; LILRA6; Lilrb3; LIR-3; LIR3; PIR-B; PIRB
UniProt ID: (Mouse) P97484
Entrez Gene ID: (Human) 11025, (Mouse) 18733
adaptive immune response
immune system process
immune response-regulating signaling pathway
defense response
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
negative regulation of osteoclast differentiation
B cell homeostasis
B cell mediated immunity
myeloid dendritic cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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