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Invitrogen
Syntenin 1 Polyclonal Antibody
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FIGURE: 1 / 5
Syntenin 1 Antibody (PA5-92419) in ICC/IF
Immunofluorescence analysis of Syntenin-1 was performed using 70% confluent log phase MDA-MB-231 and MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Syntenin 1 Polyclonal Antibody (Product # PA5-92419) at 1:100 dilution in 0.1% BSA, incubated... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-92419
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2.71 mg/mL
Amount
271 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE INGQNVIGLK DSQIADILST; Positive Samples: HT-29, THP-1; Cellular Location: Cell junction, Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Melanosome, Nucleus, Peripheral membrane protein, adherens junction, cytoskeleton, cytosol, focal adhesion
Target Information
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mda-9; mda-9; pbp-1; melanoma differentiation associated protein-9; pro-TGF-alpha cytoplasmic domain-interacting protein 18; scaffold protein Pbp1; syndecan binding protein (syntenin); syndecan-binding protein 1; unnamed protein product
Gene Aliases: MDA-9; MDA9; SDCBP1; ST1; SYCL; TACIP18
UniProt ID: (Human) O00560
Entrez Gene ID: (Human) 6386
negative regulation of transcription from RNA polymerase II promoter
negative regulation of receptor internalization
protein targeting to membrane
substrate-dependent cell migration, cell extension
chemical synaptic transmission
regulation of mitotic cell cycle
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
actin cytoskeleton organization
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
intracellular signal transduction
positive regulation of phosphorylation
positive regulation of JNK cascade
positive regulation of exosomal secretion
positive regulation of extracellular exosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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