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Invitrogen

SHP2 Polyclonal Antibody

1 Published Figure
1 Reference
View all (47) SHP2 antibodies

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SHP2 Polyclonal Antibody

Product Details

PA5-95069

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-

Flow Cytometry (Flow)

1-3 µg/1x10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SHP2 (582-597aa RVYENVGLMQQQKSFR).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL once reconstituted

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806875

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Jurkat whole cell, human CCRF-CEM whole cell, human Raji whole cell, human PC-3 whole cell, rat brain tissuerat C6 whole cellmouse brain tissuemouse 3T3-L1 whole cell. IHC: human lung tissue. ICC/IF: PC-3 cell. Flow: CACO-2 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 2SH2 domain protein; encodes catalytic domain; HCP; HGNC:9644; MGC14433; Mutations: 351:OK; Noonan syndrome 1; OTTHUMP00000166108; protein tyrosine phosphatase SH-PTP2; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; protein-tyrosine phosphatase SYP; PTP-1D; PTP1C; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SH2 domain-containing protein tyrosine phosphatase 2; SH2 domain-containing protein tyrosine phosphatase-2; SHP-2; unnamed protein product

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Gene Aliases: 2700084A17Rik; BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP1D; PTP2C; SAP-2; SH-PTP2; SH-PTP3; SHP-2; SHP2; Syp

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UniProt ID: (Human) Q06124, (Rat) P41499, (Mouse) P35235

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Entrez Gene ID: (Human) 5781, (Rat) 25622, (Mouse) 19247

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Function(s)
phosphotyrosine binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity insulin receptor binding protein binding protein kinase binding receptor signaling complex scaffold activity receptor tyrosine kinase binding cadherin binding cell adhesion molecule binding peptide hormone receptor binding binding, bridging protein tyrosine kinase binding protein domain specific binding D1 dopamine receptor binding phospholipase binding insulin receptor substrate binding
Process(es)
epidermal growth factor receptor signaling pathway brain development heart development fibroblast growth factor receptor signaling pathway cytokine-mediated signaling pathway T cell costimulation positive regulation of lipopolysaccharide-mediated signaling pathway negative regulation of chondrocyte differentiation negative regulation of type I interferon production positive regulation of interferon-beta production positive regulation of tumor necrosis factor production negative regulation of cell adhesion mediated by integrin peptidyl-tyrosine dephosphorylation atrioventricular canal development ERBB signaling pathway negative regulation of T cell proliferation vasodilation regulation of protein complex assembly positive regulation of ossification positive regulation of glucose import positive regulation of insulin receptor signaling pathway ephrin receptor signaling pathway genitalia development inner ear development negative regulation of antigen receptor-mediated signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of T cell activation positive regulation of protein kinase B signaling face morphogenesis regulation of type I interferon-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus cellular response to epidermal growth factor stimulus positive regulation of intracellular signal transduction negative regulation of neutrophil activation DNA damage checkpoint protein dephosphorylation lipid metabolic process triglyceride metabolic process integrin-mediated signaling pathway axonogenesis hormone-mediated signaling pathway positive regulation of signal transduction cerebellar cortex formation platelet formation microvillus organization multicellular organism growth organ growth megakaryocyte development hormone metabolic process glucose homeostasis regulation of MAPK cascade positive regulation of mitotic cell cycle negative regulation of insulin secretion regulation of protein export from nucleus positive regulation of hormone secretion negative regulation of hormone secretion platelet-derived growth factor receptor signaling pathway neurotrophin TRK receptor signaling pathway smooth muscle cell proliferation homeostasis of number of cells within a tissue negative regulation of cortisol secretion positive regulation of focal adhesion assembly Bergmann glial cell differentiation negative regulation of growth hormone secretion intestinal epithelial cell migration cellular response to hydrogen peroxide cellular response to angiotensin cellular response to insulin-like growth factor stimulus regulation of lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production regulation of tumor necrosis factor production regulation of cell adhesion mediated by integrin
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