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Invitrogen

TRAF2 Polyclonal Antibody

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TRAF2 Polyclonal Antibody

Product Details

PA5-95105

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human TRAF2 (305-325aa RQHRLDQDKIEALSSKVQQLE).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL once reconstituted

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806911

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Raji whole cell, rat PC-12 whole cell, mouse spleen tissue. IHC: Human Tonsil Tissue. ICC/IF: HELA Cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adapter protein; E3 ubiquitin-protein ligase TRAF2; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TRAF family protein; tumor necrosis factor type 2 receptor associated protein 3; unnamed protein product

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Gene Aliases: MGC:45012; RNF117; TRAP; TRAP3

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UniProt ID: (Human) Q12933, (Mouse) P39429

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Entrez Gene ID: (Human) 7186, (Mouse) 22030, (Rat) 311786

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Function(s)
ubiquitin-protein transferase activity tumor necrosis factor receptor binding CD40 receptor binding protein binding zinc ion binding enzyme binding protein kinase binding protein phosphatase binding protein binding, bridging mitogen-activated protein kinase kinase kinase binding ubiquitin protein ligase binding thioesterase binding tumor necrosis factor receptor superfamily binding signaling adaptor activity identical protein binding tumor necrosis factor binding macromolecular complex binding sphingolipid binding metal ion binding ubiquitin protein ligase activity
Process(es)
toll-like receptor signaling pathway regulation of production of molecular mediator of immune response positive regulation of T cell cytokine production inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of gene expression programmed cell death protein ubiquitination CD40 signaling pathway positive regulation of interleukin-2 production tumor necrosis factor-mediated signaling pathway negative regulation of glial cell apoptotic process response to endoplasmic reticulum stress NIK/NF-kappaB signaling T cell activation regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly regulation of MAPK cascade positive regulation of JUN kinase activity regulation of JNK cascade mRNA stabilization protein autoubiquitination protein-containing complex assembly intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress protein K63-linked ubiquitination interleukin-17-mediated signaling pathway positive regulation of pyroptotic inflammatory response CD27 signaling pathway positive regulation of tumor necrosis factor-mediated signaling pathway TORC1 complex assembly TORC2 complex disassembly positive regulation of extrinsic apoptotic signaling pathway regulation of immunoglobulin production protein catabolic process TORC1 signaling TORC2 signaling negative regulation of apoptotic process innate immune response cellular response to nitric oxide programmed necrotic cell death
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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