Search
Invitrogen
TIMP2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
TIMP2 Antibody (PA5-95330) in WB
Western blot analysis of TIMP2 in Lane 1: rat spleen tissue lysate (50 µg), Lane 2: rat testis tissue lysate (50 µg), Lane 3: mouse brain tissue lysate (50 µg), Lane 4: mouse thymus tissue lysate (50 µg), Lane 5: HeLa whole cell lysate (40 µg). Samples were incubated with TIMP2 polyclonal antibody (Product # PA5-95330).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95330
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human TIMP2 recombinant protein (Position: C27-P220).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Human TIMP2 shares 98.5% amino acid (aa) sequence identity with both mouse and rat TIMP2.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Spleen Tissue, Rat Testis Tissue, Mouse Brain Tissue, Mouse Thymus Tissue, HELA whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: metalloproteinase inhibitor precursor; metalloproteinase-2 inhibitor precursor; testicular secretory protein Li 57; testicular tissue inhibitor of metalloproteases-2; TIMP 2; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2; unnamed protein product
Gene Aliases: CSC-21K; D11Bwg1104e; DDC8; Timp-2
UniProt ID: (Human) P16035, (Rat) P30121
Entrez Gene ID: (Human) 7077, (Mouse) 21858, (Rat) 29543
response to hormone
response to cytokine
negative regulation of proteolysis
negative regulation of membrane protein ectodomain proteolysis
negative regulation of metallopeptidase activity
negative regulation of cell proliferation
regulation of Rap protein signal transduction
regulation of MAPK cascade
positive regulation of MAPK cascade
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of adenylate cyclase activity
negative regulation of mitotic cell cycle
negative regulation of Ras protein signal transduction
spermatogenesis
response to xenobiotic stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support