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Invitrogen
Phospho-SLC6A4 (Thr276) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-SLC6A4 (Thr276) Antibody (PA5-95680) in WB
Western blot of SLC6A4 in rat mid brain membrane lysate showing specific immunolabeling of a band at ~76 kDa corresponding to Phospho-SLC6A4 (Thr276) polyclonal antibody (Product # PA5-95680) in the first lane (-). Phosphospecificity is shown in the second lane (+) where Immunolabeling is blocked by pre-adsorption of the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide (not sh... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95680
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr276 conjugated to KLH
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen Affinity Chromatography
Storage buffer
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 0.15M NaCl
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antigen Affinity Purified from Pooled Serum
Target Information
SERT is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5 OCD1; 5-hydroxytryptamine (serotonin) transporter; 5HT transporter; 5HTT; HGNC:11050; OTTHUMP00000163633; serotonin transporter; Sodium-dependent serotonin transporter (5HT transporter) (5HTT); Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; solute carrier family 6 member 4
Gene Aliases: 5-HTT; Htt; SERT
UniProt ID: (Mouse) Q60857, (Rat) P31652
Entrez Gene ID: (Mouse) 15567, (Rat) 25553
integrin binding
cation channel activity
neurotransmitter transporter activity
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
antiporter activity
cocaine binding
sodium ion binding
identical protein binding
nitric-oxide synthase binding
actin filament binding
serotonin binding
syntaxin-1 binding
response to hypoxia
neurotransmitter transport
amino acid transport
serotonin receptor signaling pathway
response to nutrient
memory
circadian rhythm
locomotory behavior
response to xenobiotic stimulus
response to toxic substance
positive regulation of gene expression
positive regulation of serotonin secretion
negative regulation of cerebellar granule cell precursor proliferation
regulation of transmembrane transporter activity
negative regulation of synaptic transmission, dopaminergic
response to estradiol
sodium ion transmembrane transport
vasoconstriction
negative regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of organ growth
behavioral response to cocaine
enteric nervous system development
brain morphogenesis
serotonin uptake
membrane depolarization
male mating behavior
platelet aggregation
cellular response to retinoic acid
cellular response to cGMP
regulation of thalamus size
neurotransmitter reuptake
response to oxidopamine
conditioned place preference
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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