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Invitrogen
ID4 Polyclonal Antibody
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FIGURE: 1 / 1
ID4 Antibody (PA5-95723) in WB
Western blot analysis of ID4 in mouse kidney. Samples were incubated with ID4 Polyclonal antibody (Product # PA5-95723) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95723
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ID4 (NP_0015371)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.54 mg/mL
Amount
154 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY
Target Information
ID4 is transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: inhibitor of differentiation 4; inhibitor of DNA binding 4, dominant negative helix-loop-helix protein; inhibitor of DNA binding 4, HLH protein; unnamed protein product
Gene Aliases: bHLHb27; Idb4
UniProt ID: (Mouse) P41139
Entrez Gene ID: (Rat) 291023, (Mouse) 15904
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
neuroblast proliferation
brain development
circadian rhythm
protein localization
positive regulation of cell proliferation
positive regulation of gene expression
hippocampus development
cerebral cortex neuron differentiation
central nervous system myelination
cell differentiation
neuron differentiation
fat cell differentiation
negative regulation of fat cell differentiation
negative regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
prostate gland morphogenesis
prostate gland epithelium morphogenesis
prostate gland stromal morphogenesis
seminal vesicle morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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