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Invitrogen
KIF2A Polyclonal Antibody
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FIGURE: 1 / 2
KIF2A Antibody (PA5-95751) in WB
Western blot analysis of KIF2A in extracts of various cell lines. Samples were incubated with KIF2A Polyclonal antibody (Product # PA5-95751) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-95751
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 30-220 of human KIF2A (NP_0045112)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.59 mg/mL
Amount
59 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TSLNEDNESV TVEWIENGDT KGKEIDLESI FSLNPDLVPD EEIEPSPETP PPPASSAKVN KIVKNRRTVA SIKNDPPSRD NRVVGSARAR PSQFPEQSSS AQQNGSVSDI SPVQAAKKEF GPPSRRKSNC VKEVEKLQEK REKRRLQQQE LREKRAQDVD ATNPNYEIMC MIRDFRGSLD YRPLTTADPI D; Positive Samples: Rat brain; Cellular Location: Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle, spindle pole
Target Information
KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: kinesin heavy chain family, member 2; kinesin heavy chain member 2; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; kinesin-2; unnamed protein product
Gene Aliases: C530030B14Rik; CDCBM3; HK2; KIF2; Kns2; M-kinesin
UniProt ID: (Human) O00139, (Mouse) P28740
Entrez Gene ID: (Human) 3796, (Rat) 84391, (Mouse) 16563
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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