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Invitrogen
LKB1 Polyclonal Antibody
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Product Details
PA5-96062
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 134-433 of human LKB1 (NP_0004461)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.75 mg/mL
Amount
75 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CGMQEMLDSV PEKRFPVCQA HGYFCQLIDG LEYLHSQGIV HKDIKPGNLL LTTGGTLKIS DLGVAEALHP FAADDTCRTS QGSPAFQPPE IANGLDTFSG FKVDIWSAGV TLYNITTGLY PFEGDNIYKL FENIGKGSYA IPGDCGPPLS DLLKGMLEYE PAKRFSIRQI RQHSWFRKKH PPAEAPVPIP PSPDTKDRWR SMTVVPYLED LHGADEDEDL FDIEDDIIYT QDFTVPGQVP EEEASHNGQR RGLPKAVCMN GTEAAQLSTK SRAEGRAPNP ARKACSASSK IRRLSACKQQ; Positive Samples: U-87MG, SKOV3, Mouse heart; Cellular Location: Cytoplasm, Membrane, Mitochondrion, Nucleus
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CAMK group; CAMKL family; Liver kinase B1; Liver kinase B1 homolog; LKB 1; LKB-1; LKB1; LKB1(S); polarization-related protein LKB1; Renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; STK11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; Serine/threonine-protein kinase STK11; unnamed protein product
Gene Aliases: AA408040; hLKB1; LKB1; Par-4; PJS; R75140; STK11
UniProt ID: (Human) Q15831, (Rat) D4AE59, (Mouse) Q9WTK7
Entrez Gene ID: (Human) 6794, (Rat) 314621, (Mouse) 20869
nucleotide binding
magnesium ion binding
p53 binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
LRR domain binding
protein kinase activator activity
metal ion binding
protein serine kinase activity
protein complex binding
regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
response to glucagon
response to lipid
TCR signalosome assembly
glucose homeostasis
anoikis
response to peptide hormone
positive thymic T cell selection
positive regulation of gluconeogenesis
positive regulation of protein kinase activity
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
protein heterooligomerization
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
protein dephosphorylation
apoptotic process
signal transduction
spermatogenesis
positive regulation of autophagy
peptidyl-threonine phosphorylation
cell differentiation
protein localization to nucleus
regulation of cell cycle
epithelial cell proliferation involved in prostate gland development
G1 to G0 transition
negative regulation of canonical Wnt signaling pathway
negative regulation of cold-induced thermogenesis
positive regulation of vesicle transport along microtubule
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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