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Invitrogen
Caspase 3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96077
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.29 mg/mL
Amount
29 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Jurkat; Cellular Location: Cytoplasm
Immunogen sequence: FHKSTGMTSR SGTDVDAANL RETFRNLKYE VRNKNDLTRE EIVELMRDVS KEDHSKRSSF VCVLLSHGEE GIIFGTNGPV DLKKITNFFR GDRCRSLTGK PKLFII
Target Information
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apopain; Apopain precursor; CASP-3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase-3; Caspase3; CPP-32; CPP32beta; Cysteine protease CPP32; ICE3; IRP; LICE; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; SREBP cleavage activity 1; unnamed protein product; yama protein
Gene Aliases: A830040C14Rik; AC-3; Apopain; CASP-3; CASP3; Caspase-3; CC3; CPP-32; CPP32; CPP32B; Lice; mldy; SCA-1; Yama
UniProt ID: (Mouse) P70677, (Rat) P55213
Entrez Gene ID: (Human) 836, (Mouse) 12367, (Rat) 25402
protease binding
endopeptidase activity
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity
cyclin-dependent protein serine/threonine kinase inhibitor activity
death receptor binding
protein binding
enzyme activator activity
peptidase activity
cysteine-type peptidase activity
phospholipase A2 activator activity
macromolecular complex binding
hydrolase activity
protein complex binding
cysteine-type endopeptidase activity involved in apoptotic process
cysteine-type endopeptidase activity involved in execution phase of apoptosis
protease
luteolysis
response to hypoxia
negative regulation of cytokine production
proteolysis
apoptotic process
axonal fasciculation
learning or memory
intrinsic apoptotic signaling pathway in response to osmotic stress
response to xenobiotic stimulus
response to glucose
response to metal ion
response to X-ray
regulation of macroautophagy
protein processing
hippocampus development
protein catabolic process
neuron differentiation
keratinocyte differentiation
erythrocyte differentiation
platelet formation
regulation of protein stability
response to cobalt ion
response to estradiol
response to lipopolysaccharide
regulation of protein localization
glial cell apoptotic process
response to tumor necrosis factor
response to nicotine
intracellular signal transduction
swimming behavior
response to hydrogen peroxide
positive regulation of apoptotic process
response to amino acid
regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
response to ethanol
neurotrophin TRK receptor signaling pathway
striated muscle cell differentiation
response to glucocorticoid
protein maturation
pyroptosis
leukocyte apoptotic process
response to anesthetic
cellular response to staurosporine
apoptotic signaling pathway
intrinsic apoptotic signaling pathway
execution phase of apoptosis
regulation of synaptic vesicle cycle
synapse pruning
positive regulation of pyroptotic inflammatory response
positive regulation of beta-amyloid formation
positive regulation of apoptotic DNA fragmentation
response to insulin-like growth factor stimulus
B cell homeostasis
cellular response to DNA damage stimulus
heart development
sensory perception of sound
response to UV
response to wounding
negative regulation of B cell proliferation
T cell homeostasis
negative regulation of apoptotic process
positive regulation of catalytic activity
cell fate commitment
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of activated T cell proliferation
neuron apoptotic process
cellular response to organic substance
release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway via death domain receptors
intrinsic apoptotic signaling pathway in response to oxidative stress
response to organic substance
response to organic cyclic compound
wound healing
response to drug
response to antibiotic
cellular response to organic cyclic compound
extrinsic apoptotic signaling pathway in absence of ligand
regulation of apoptotic DNA fragmentation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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