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Invitrogen

KCNQ1 Polyclonal Antibody

View all (25) KCNQ1 antibodies

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KCNQ1 Polyclonal Antibody

Product Details

PA5-96082

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 250-549 of human KCNQ1 (NP_8614631)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Amount

26 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807884

Product Specific Information

Immunogen sequence: TAWRCYAAEN PDSSTWKIYI RKAPRSHTLL SPSPKPKKSV VVKKKKFKLD KDNGVTPGEK MLTVPHITCD PPEERRLDHF SVDGYDSSVR KSPTLLEVSM PHFMRTNSFA EDLDLEGETL LTPITHISQL REHHRATIKV IRRMQYFVAK KKFQQARKPY DVRDVIEQYS QGHLNLMVRI KELQRRLDQS IGKPSLFISV SEKSKDRGSN TIGARLNRVE DKVTQLDQRL ALITDMLHQL LSLHGGSTPG SGGPPREGGA HITQPCGSGG SVDPELFLPS NTLPTYEQLT VPRRGPDEGS; Positive Samples: HT-29, SW620, Mouse kidney, BT-474; Cellular Location: Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein

Target Information

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. A specific K+ channel, comprised of an alpha subunit KCNQ1 and a beta subunit KCNE1, a small protein which spans the membrane only once, is predominantly expressed in the heart and in the cochlea, and is responsible for regulating the slow, depolarization-activated potassium current. Mutations in the genes encoding for KCNQ1 and KCNE1 lead to cardiac disease because they directly impair electrical signaling, and mutations in KCNQ4 are implicated in the onset of deafness. KCNQ proteins, including KCNQ1 and KCNQ4, characteristically contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including the cochlea, where it is present in outer hair cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ26167; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; Kcnq1; kidney and cardiac voltage dependend K+ channel; KQT-like 1; KQT-like subfamily member 1; potassium channel, voltage gated KQT-like subfamily Q, member 1; potassium channel, voltage-gated KQT-like subfamily Q, member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; slow delayed rectifier channel subunit; tKvLQT1; unnamed protein product; voltage-gated potassium channel subunit Kv7.1

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Gene Aliases: ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS

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UniProt ID: (Human) P51787, (Rat) Q9Z0N7, (Mouse) P97414

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Entrez Gene ID: (Human) 3784, (Rat) 84020, (Mouse) 16535

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Function(s)
ion channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity protein binding calmodulin binding phosphatidylinositol-4,5-bisphosphate binding protein phosphatase 1 binding outward rectifier potassium channel activity ubiquitin protein ligase binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding ion channel binding voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization scaffold protein binding voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization potassium channel activity identical protein binding
Process(es)
action potential gastric acid secretion gastrin-induced gastric acid secretion regulation of heart rate glucose metabolic process ion transport potassium ion transport sodium ion transport heart development sensory perception of sound rhythmic behavior regulation of blood pressure male gonad development positive regulation of heart rate regulation of hormone levels iodide transport digestive system process erythrocyte differentiation cellular chloride ion homeostasis response to insulin social behavior corticosterone secretion regulation of membrane potential inner ear morphogenesis negative regulation of insulin secretion inner ear development intestinal absorption neuromuscular process detection of mechanical stimulus involved in sensory perception of sound regulation of transport chloride ion homeostasis potassium ion homeostasis transmembrane transport cardiac muscle contraction auditory receptor cell development regulation of membrane repolarization regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization positive regulation of cardiac muscle contraction regulation of gastric acid secretion cardiac conduction stomach development renal absorption renal sodium ion absorption cellular response to cAMP cellular response to xenobiotic stimulus potassium ion transmembrane transport cellular response to epinephrine stimulus adrenergic receptor signaling pathway response to anesthetic ventricular cardiac muscle cell action potential membrane repolarization membrane repolarization during action potential membrane repolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential regulation of heart rate by cardiac conduction cochlea development potassium ion export across plasma membrane membrane repolarization during atrial cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential positive regulation of potassium ion transmembrane transport negative regulation of delayed rectifier potassium channel activity negative regulation of voltage-gated potassium channel activity regulation of voltage-gated sodium channel activity non-motile cilium assembly potassium ion import across plasma membrane cardiac muscle cell contraction system process regulation of heart contraction
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