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Invitrogen
p70 S6 Kinase Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-96090
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.22 mg/mL
Amount
22 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Raji, MCF7, A-549, PC-3, DU145, Mouse brain, Mouse kidney; Cellular Location: Cell junction, Cytoplasm, Mitochondrion outer membrane, Mitochondrion, Nucleus, synapse, synaptosome
Immunogen sequence: SVKEKFSFEP KIRSPRRFIG SPRTPVSPVK FSPGDFWGRG ASASTANPQT PVEYPMETSG IEQMDVTMSG EASAPLPIRQ PNSGPYKKQA FPMISKRPEH
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 70 kDa ribosomal protein S6 kinase 1; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6KA; p70(S6K)-alpha; p70-S6K 1; P70S6K; p70S6K-alpha; P70S6K1; p80-S6K 1; p85 p85S6K; ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, polypeptide 1; S6 kinase; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; unnamed protein product
Gene Aliases: 2610318I15Rik; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70-S6K 1; p70/85s6k; p70s6k; P70S6K1; PS6K; S6K; S6K-beta-1; S6K1; STK14A
UniProt ID: (Human) P23443, (Rat) P67999, (Mouse) Q8BSK8
Entrez Gene ID: (Human) 6198, (Rat) 83840, (Mouse) 72508
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
protein serine kinase activity
ribosomal protein S6 kinase activity
PDZ domain binding
peptide binding
identical protein binding
protein phosphatase 2A binding
G1/S transition of mitotic cell cycle
behavioral fear response
skeletal muscle contraction
protein phosphorylation
signal transduction
germ cell development
response to nutrient
long-term memory
response to xenobiotic stimulus
response to mechanical stimulus
response to toxic substance
response to glucose
skeletal muscle atrophy
response to electrical stimulus involved in regulation of muscle adaptation
positive regulation of smooth muscle cell migration
cell migration
peptidyl-serine phosphorylation
response to nutrient levels
cellular response to nutrient
TOR signaling
response to lipopolysaccharide
response to insulin
cellular response to insulin stimulus
cellular response to hormone stimulus
response to testosterone
response to glucagon
response to tumor necrosis factor
TORC1 signaling
negative regulation of apoptotic process
response to amino acid
response to leucine
response to peptide hormone
regulation of kinase activity
long-chain fatty acid import
response to ethanol
positive regulation of translation
positive regulation of mitotic cell cycle
positive regulation of translational initiation
regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of mRNA splicing, via spliceosome
positive regulation of skeletal muscle tissue growth
positive regulation of smooth muscle cell proliferation
modulation of synaptic transmission
response to glucocorticoid
response to other organism
cellular response to interferon-gamma
cellular response to growth factor stimulus
cellular response to dexamethasone stimulus
response to ketone
negative regulation of TORC2 signaling
positive regulation of TORC1 signaling
response to methamphetamine hydrochloride
negative regulation of extrinsic apoptotic signaling pathway
phosphatidylinositol-mediated signaling
autophagosome assembly
cytoplasmic translation
ubiquitin-dependent protein catabolic process
insulin receptor signaling pathway
negative regulation of autophagy
positive regulation of autophagy
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
cellular response to nutrient levels
TORC2 signaling
protein kinase B signaling
positive regulation of protein kinase B signaling
negative regulation of TORC1 signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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